Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model
Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian Tualang honey (TH) and Australian/New Zealand...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
Hindawi Publishing Corporation
2017
|
| Subjects: | |
| Online Access: | https://doi.org/10.1155/2017/5904361 https://doi.org/10.1155/2017/5904361 http://eprints.usm.my/37099/1/(Oral_Administration_of_Tualang)_5904361.pdf |
| Summary: | Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of
complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian
Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Thirty syngeneic virgin
female Sprague-Dawley (SD) rats were induced by the carcinogen 1-methyl-1-nitrosourea (MNU) 80mg/kg. The treatment started
when first palpable tumour reached 10–12mm in size by dividing rats into following groups: Group 0 (negative control); Group
1 (positive control); and Groups 2 and 3 which received 1.0 g/kg body weight/day of TH and MH, respectively, for 120 days.
The data demonstrate that cancer masses in TH and MH treated groups showed a lower median tumour size, weight, and
multiplicity compared with the nontreated positive control ( |
|---|