Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models

Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models

Mitraginina adalah alkaloid aktif utama yang dipencil daripada daun Mitragyna speciosa atau kratom. Sementara mitraginina atau kratom menghasilkan kesan-kesan analgesik, anti-radang dan relaksi otot, namun sedikit yang telah diketahui tentang sifat-sifat penyalahgunaan dan penagihannya. Diberikan ke...

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Main Author: Harun, Norsyifa
Format: Thesis
Published: 2016
Subjects:
RM300-666 Drugs and their actions
Online Access:http://ezproxy.usm.my/login?url=http://ethesis.usm.my/jspui
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http://eprints.usm.my/31846/1/NORSYIFA_BINTI_HARUN_24(NN).pdf
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recordtype eprints
spelling usm-318462018-05-17T03:10:51Z Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models Harun, Norsyifa RM300-666 Drugs and their actions Mitraginina adalah alkaloid aktif utama yang dipencil daripada daun Mitragyna speciosa atau kratom. Sementara mitraginina atau kratom menghasilkan kesan-kesan analgesik, anti-radang dan relaksi otot, namun sedikit yang telah diketahui tentang sifat-sifat penyalahgunaan dan penagihannya. Diberikan kemungkinan kepentingan sistem opioid dalam perantaraan kesan-kesan farmakologi mitraginina, kajian ini bertujuan meninjau kesan-kesan tingkah laku daripada mitraginina menggunakan tatacara pendiskriminasian drug dan pemberian sendiri drug. Tikus jantan jenis Sprague Dawley telah dilatih untuk mendiskriminasi antara mitraginina dan pembawa menggunakan tatacara pendiskriminasian drug dua tuil di bawah pembolehubah selang secara tandem (VI-60 saat) dan nisbah tetap (FR-10) dalam jadual pengukuhan makanan. Tikus-tikus itu telah berjaya memperoleh pendiskriminasian mitraginina (15.0 mg/kg, i.p.) yang mirip dengan kumpulan tikus yang satu lagi dengan pendiskriminasian morfina (5.0 mg/kg, i.p.) Mitragynine is the main active alkaloid isolated from the leaves of Mitragyna speciosa or kratom. While mitragynine or kratom provides analgesic, anti-inflammatory and muscle relaxant effects, little is known about its abuse and addictive properties. Given the likely importance of opioid system in mediating the pharmacological effects of mitragynine, the present study aims to explore the behavioural effects of mitragynine using drug discrimination and drug self-administration procedures. Male Sprague Dawley rats were trained to discriminate between mitragynine and vehicle in two-lever drug discrimination procedure under a tandem variable-interval (VI-60 sec) and fixed-ratio (FR-10) schedule of food reinforcement. The rats successfully acquired mitragynine discrimination (15.0 mg/kg, i.p.) which was similar to another group of rats with morphine discrimination (5.0 mg/kg, i.p.). 2016-03 Thesis NonPeerReviewed application/pdf http://eprints.usm.my/31846/1/NORSYIFA_BINTI_HARUN_24(NN).pdf http://ezproxy.usm.my/login?url=http://ethesis.usm.my/jspui Harun, Norsyifa (2016) Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models. PhD thesis, Universiti Sains Malaysia. http://eprints.usm.my/31846/
institution Universiti Sains Malaysia
Universiti Sains Malaysia
repository_type Digital Repository
institution_category Local University
building USM Repository
collection Online Access
topic RM300-666 Drugs and their actions
spellingShingle RM300-666 Drugs and their actions
Harun, Norsyifa
Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
description Mitraginina adalah alkaloid aktif utama yang dipencil daripada daun Mitragyna speciosa atau kratom. Sementara mitraginina atau kratom menghasilkan kesan-kesan analgesik, anti-radang dan relaksi otot, namun sedikit yang telah diketahui tentang sifat-sifat penyalahgunaan dan penagihannya. Diberikan kemungkinan kepentingan sistem opioid dalam perantaraan kesan-kesan farmakologi mitraginina, kajian ini bertujuan meninjau kesan-kesan tingkah laku daripada mitraginina menggunakan tatacara pendiskriminasian drug dan pemberian sendiri drug. Tikus jantan jenis Sprague Dawley telah dilatih untuk mendiskriminasi antara mitraginina dan pembawa menggunakan tatacara pendiskriminasian drug dua tuil di bawah pembolehubah selang secara tandem (VI-60 saat) dan nisbah tetap (FR-10) dalam jadual pengukuhan makanan. Tikus-tikus itu telah berjaya memperoleh pendiskriminasian mitraginina (15.0 mg/kg, i.p.) yang mirip dengan kumpulan tikus yang satu lagi dengan pendiskriminasian morfina (5.0 mg/kg, i.p.) Mitragynine is the main active alkaloid isolated from the leaves of Mitragyna speciosa or kratom. While mitragynine or kratom provides analgesic, anti-inflammatory and muscle relaxant effects, little is known about its abuse and addictive properties. Given the likely importance of opioid system in mediating the pharmacological effects of mitragynine, the present study aims to explore the behavioural effects of mitragynine using drug discrimination and drug self-administration procedures. Male Sprague Dawley rats were trained to discriminate between mitragynine and vehicle in two-lever drug discrimination procedure under a tandem variable-interval (VI-60 sec) and fixed-ratio (FR-10) schedule of food reinforcement. The rats successfully acquired mitragynine discrimination (15.0 mg/kg, i.p.) which was similar to another group of rats with morphine discrimination (5.0 mg/kg, i.p.).
format Thesis
author Harun, Norsyifa
author_facet Harun, Norsyifa
author_sort Harun, Norsyifa
title Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
title_short Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
title_full Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
title_fullStr Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
title_full_unstemmed Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models
title_sort studies of mitragynine, the principle alkaloid of mitragyna speciosa korth (kratom) on its abuse and addictive properties in rat behavioural models
publishDate 2016
url http://ezproxy.usm.my/login?url=http://ethesis.usm.my/jspui
http://ezproxy.usm.my/login?url=http://ethesis.usm.my/jspui
http://eprints.usm.my/31846/1/NORSYIFA_BINTI_HARUN_24(NN).pdf
first_indexed 2018-09-08T08:29:21Z
last_indexed 2018-09-08T08:29:21Z
_version_ 1611027302850756608

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