Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia

Objective: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of pa...

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Main Authors:	Abdul Aziz, Zariah, Lee, Yvonne Y. L., Sidek, Norsima Nazifah, Awang Ngah, Bahari, Looi, Irene, Hanip, Md.Rafia, Basri, Hamidon
Format:	Article
Language:	English
Published:	Taylor & Francis 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/1/Gender%20disparities%20and%20thrombolysis%20use%20among%20patient%20with%20first-ever%20ischemic%20stroke%20in%20Malaysia.pdf

id	upm-54369
recordtype	eprints
spelling	upm-543692018-03-14T07:21:48Z http://psasir.upm.edu.my/id/eprint/54369/ Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia Abdul Aziz, Zariah Lee, Yvonne Y. L. Sidek, Norsima Nazifah Awang Ngah, Bahari Looi, Irene Hanip, Md.Rafia Basri, Hamidon Objective: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. Methods: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. Results: A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender–age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. Discussion: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male. Taylor & Francis 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54369/1/Gender%20disparities%20and%20thrombolysis%20use%20among%20patient%20with%20first-ever%20ischemic%20stroke%20in%20Malaysia.pdf Abdul Aziz, Zariah and Lee, Yvonne Y. L. and Sidek, Norsima Nazifah and Awang Ngah, Bahari and Looi, Irene and Hanip, Md.Rafia and Basri, Hamidon (2016) Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia. Neurological Research, 38 (5). pp. 406-413. ISSN 0161-6412; ESSN: 1743-1328 https://www.tandfonline.com/doi/abs/10.1080/01616412.2016.1178948?journalCode=yner20 10.1080/01616412.2016.1178948
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Putra Malaysia
building	UPM Institutional Repository
collection	Online Access
language	English
description	Objective: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. Methods: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. Results: A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender–age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. Discussion: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.
format	Article
author	Abdul Aziz, Zariah Lee, Yvonne Y. L. Sidek, Norsima Nazifah Awang Ngah, Bahari Looi, Irene Hanip, Md.Rafia Basri, Hamidon
spellingShingle	Abdul Aziz, Zariah Lee, Yvonne Y. L. Sidek, Norsima Nazifah Awang Ngah, Bahari Looi, Irene Hanip, Md.Rafia Basri, Hamidon Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
author_facet	Abdul Aziz, Zariah Lee, Yvonne Y. L. Sidek, Norsima Nazifah Awang Ngah, Bahari Looi, Irene Hanip, Md.Rafia Basri, Hamidon
author_sort	Abdul Aziz, Zariah
title	Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
title_short	Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
title_full	Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
title_fullStr	Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
title_full_unstemmed	Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia
title_sort	gender disparities and thrombolysis use among patient with first-ever ischemic stroke in malaysia
publisher	Taylor & Francis
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/ http://psasir.upm.edu.my/id/eprint/54369/1/Gender%20disparities%20and%20thrombolysis%20use%20among%20patient%20with%20first-ever%20ischemic%20stroke%20in%20Malaysia.pdf
first_indexed	2018-09-07T18:28:28Z
last_indexed	2018-09-07T18:28:28Z
_version_	1610974398900076544

Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia

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