Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants

Methanol extracts of seven Malaysian medicinal plants were screened for antioxidant and nitric oxide inhibitory activities. Antioxidant activity was measured by using FTC, TBA and DPPH free radical scavenging methods and Griess assay was used for the measurement of nitric oxide inhibition in lipopol...

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Main Authors:	Saha, Koushik, Lajis, Nordin, Ahmad Israf, Daud, Hamzah, Ahmad Sazali, Shaari, Khozirah, Khamis, Shamsul, Ahmad, Syahida
Format:	Article
Language:	English
Published:	Elsevier 2004
Online Access:	http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/1/Evaluation%20of%20antioxidant%20and%20nitric%20oxide%20inhibitory%20activities%20of%20selected%20Malaysian%20medicinal%20plants.pdf

id	upm-40232
recordtype	eprints
spelling	upm-402322015-09-17T00:47:43Z http://psasir.upm.edu.my/id/eprint/40232/ Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants Saha, Koushik Lajis, Nordin Ahmad Israf, Daud Hamzah, Ahmad Sazali Shaari, Khozirah Khamis, Shamsul Ahmad, Syahida Methanol extracts of seven Malaysian medicinal plants were screened for antioxidant and nitric oxide inhibitory activities. Antioxidant activity was measured by using FTC, TBA and DPPH free radical scavenging methods and Griess assay was used for the measurement of nitric oxide inhibition in lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-treated RAW 264.7 cells. All the extracts showed strong antioxidant activity comparable to or higher than that of α-tocopherol, BHT and quercetin in FTC and TBA methods. The extracts from Leea indica and Spermacoce articularis showed strong DPPH free radical scavenging activity comparable with quercetin, BHT and Vit C. Spermacoce exilis showed only moderate activity but other species were weak as compared to the standards. In the Griess assay Lasianthus oblongus, Chasalia chartacea, Hedyotis verticillata, Spermacoce articularis and Leea indica showed strong inhibitory activity on nitric oxide production in LPS and IFN-γ-induced RAW 264.7 cells. Extracts from Psychotria rostrata and Spermacoce exilis also inhibited NO production but this was due to their cytotoxic effects upon cells during culture. Elsevier 2004-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40232/1/Evaluation%20of%20antioxidant%20and%20nitric%20oxide%20inhibitory%20activities%20of%20selected%20Malaysian%20medicinal%20plants.pdf Saha, Koushik and Lajis, Nordin and Ahmad Israf, Daud and Hamzah, Ahmad Sazali and Shaari, Khozirah and Khamis, Shamsul and Ahmad, Syahida (2004) Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants. Journal of Ethnopharmacology, 92 (2-3). pp. 263-267. ISSN 0378-8741; ESSN: 1872-7573 http://www.sciencedirect.com/science/article/pii/S0378874104001096 10.1016/j.jep.2004.03.007
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Putra Malaysia
building	UPM Institutional Repository
collection	Online Access
language	English
description	Methanol extracts of seven Malaysian medicinal plants were screened for antioxidant and nitric oxide inhibitory activities. Antioxidant activity was measured by using FTC, TBA and DPPH free radical scavenging methods and Griess assay was used for the measurement of nitric oxide inhibition in lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-treated RAW 264.7 cells. All the extracts showed strong antioxidant activity comparable to or higher than that of α-tocopherol, BHT and quercetin in FTC and TBA methods. The extracts from Leea indica and Spermacoce articularis showed strong DPPH free radical scavenging activity comparable with quercetin, BHT and Vit C. Spermacoce exilis showed only moderate activity but other species were weak as compared to the standards. In the Griess assay Lasianthus oblongus, Chasalia chartacea, Hedyotis verticillata, Spermacoce articularis and Leea indica showed strong inhibitory activity on nitric oxide production in LPS and IFN-γ-induced RAW 264.7 cells. Extracts from Psychotria rostrata and Spermacoce exilis also inhibited NO production but this was due to their cytotoxic effects upon cells during culture.
format	Article
author	Saha, Koushik Lajis, Nordin Ahmad Israf, Daud Hamzah, Ahmad Sazali Shaari, Khozirah Khamis, Shamsul Ahmad, Syahida
spellingShingle	Saha, Koushik Lajis, Nordin Ahmad Israf, Daud Hamzah, Ahmad Sazali Shaari, Khozirah Khamis, Shamsul Ahmad, Syahida Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
author_facet	Saha, Koushik Lajis, Nordin Ahmad Israf, Daud Hamzah, Ahmad Sazali Shaari, Khozirah Khamis, Shamsul Ahmad, Syahida
author_sort	Saha, Koushik
title	Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
title_short	Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
title_full	Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
title_fullStr	Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
title_full_unstemmed	Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
title_sort	evaluation of antioxidant and nitric oxide inhibitory activities of selected malaysian medicinal plants
publisher	Elsevier
publishDate	2004
url	http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/ http://psasir.upm.edu.my/id/eprint/40232/1/Evaluation%20of%20antioxidant%20and%20nitric%20oxide%20inhibitory%20activities%20of%20selected%20Malaysian%20medicinal%20plants.pdf
first_indexed	2018-09-07T16:58:45Z
last_indexed	2018-09-07T16:58:45Z
_version_	1610968754764644352

Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants

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