Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats

The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180-200 g were randomized into four groups; (C) received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered...

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Main Authors:	Ibraheem, Zaid O., Basir, Rusliza, Aljobory, Ahmad Kh., Ibrahim, Omar E., Alsumaidaee, Ajwad, Yam, Mun Fee
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/1/37950.pdf

id	upm-37950
recordtype	eprints
spelling	upm-379502015-12-15T03:36:50Z http://psasir.upm.edu.my/id/eprint/37950/ Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats Ibraheem, Zaid O. Basir, Rusliza Aljobory, Ahmad Kh. Ibrahim, Omar E. Alsumaidaee, Ajwad Yam, Mun Fee The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180-200 g were randomized into four groups; (C) received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered as control, (F) received standard rodents chow with free access to drinking water supplemented with 20% (W/V) fructose for the same abovementioned period, (FG) was fed as group F and was given 80 mg/kg (body weight)/day gentamicin sulphate intraperitoneally during the last 20 days of the feeding period, and (G) was given gentamicin as above and fed as group C. Renal function was assessed at the end of the treatment period through measuring serum creatinine, uric acid and albumin, creatinine clearance, absolute and fractional excretion of both sodium and potassium, twenty-four-hour urinary excretion of albumin, and renal histology. For metabolic syndrome assessment, fasting plasma glucose and insulin were measured and oral glucose tolerance test was performed throughout the treatment period. Results showed that gentamicin enhances progression of fructose induced metabolic syndrome. On the other hand, fructose pretreatment before gentamicin injection produced a comparable degree of renal dysfunction to those which were given fructose-free water but the picture of nephrotoxicity was somewhat altered as it was characterized by higher extent of glomerular congestion and protein urea. Overall, more vigilance is required when nephrotoxic drugs are prescribed for patients with fructose induced metabolic syndrome. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37950/1/37950.pdf Ibraheem, Zaid O. and Basir, Rusliza and Aljobory, Ahmad Kh. and Ibrahim, Omar E. and Alsumaidaee, Ajwad and Yam, Mun Fee (2014) Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats. BioMed Research International, 2014. art. no. 823879. pp. 1-10. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/823879/abs/ 10.1155/2014/823879
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Putra Malaysia
building	UPM Institutional Repository
collection	Online Access
language	English
description	The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180-200 g were randomized into four groups; (C) received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered as control, (F) received standard rodents chow with free access to drinking water supplemented with 20% (W/V) fructose for the same abovementioned period, (FG) was fed as group F and was given 80 mg/kg (body weight)/day gentamicin sulphate intraperitoneally during the last 20 days of the feeding period, and (G) was given gentamicin as above and fed as group C. Renal function was assessed at the end of the treatment period through measuring serum creatinine, uric acid and albumin, creatinine clearance, absolute and fractional excretion of both sodium and potassium, twenty-four-hour urinary excretion of albumin, and renal histology. For metabolic syndrome assessment, fasting plasma glucose and insulin were measured and oral glucose tolerance test was performed throughout the treatment period. Results showed that gentamicin enhances progression of fructose induced metabolic syndrome. On the other hand, fructose pretreatment before gentamicin injection produced a comparable degree of renal dysfunction to those which were given fructose-free water but the picture of nephrotoxicity was somewhat altered as it was characterized by higher extent of glomerular congestion and protein urea. Overall, more vigilance is required when nephrotoxic drugs are prescribed for patients with fructose induced metabolic syndrome.
format	Article
author	Ibraheem, Zaid O. Basir, Rusliza Aljobory, Ahmad Kh. Ibrahim, Omar E. Alsumaidaee, Ajwad Yam, Mun Fee
spellingShingle	Ibraheem, Zaid O. Basir, Rusliza Aljobory, Ahmad Kh. Ibrahim, Omar E. Alsumaidaee, Ajwad Yam, Mun Fee Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
author_facet	Ibraheem, Zaid O. Basir, Rusliza Aljobory, Ahmad Kh. Ibrahim, Omar E. Alsumaidaee, Ajwad Yam, Mun Fee
author_sort	Ibraheem, Zaid O.
title	Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
title_short	Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
title_full	Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
title_fullStr	Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
title_full_unstemmed	Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats
title_sort	impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in sprague-dawley rats
publisher	Hindawi Publishing Corporation
publishDate	2014
url	http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/ http://psasir.upm.edu.my/id/eprint/37950/1/37950.pdf
first_indexed	2018-09-07T16:42:06Z
last_indexed	2018-09-07T16:42:06Z
_version_	1610967707058962432

Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats

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