Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats

The aim of this study was to investigate the acute and sub-chronic toxicities of Nannochloropsis oculata biomass. In the acute toxicity study, twelve Sprague-Dawley rats of both sexes were gavaged with 12 g/kg body weight (bw) of N. oculata one time, and then tested for morbidity and mortality in 14...

Full description

Bibliographic Details
Main Authors:	Kafaie, Soroush, Loh, Su Peng, Mohtarrudin, Norhafizah
Format:	Article
Language:	English
Published:	Academic Journals 2012
Online Access:	http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/1/24699.pdf

id	upm-24699
recordtype	eprints
spelling	upm-246992017-11-08T07:39:33Z http://psasir.upm.edu.my/id/eprint/24699/ Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats Kafaie, Soroush Loh, Su Peng Mohtarrudin, Norhafizah The aim of this study was to investigate the acute and sub-chronic toxicities of Nannochloropsis oculata biomass. In the acute toxicity study, twelve Sprague-Dawley rats of both sexes were gavaged with 12 g/kg body weight (bw) of N. oculata one time, and then tested for morbidity and mortality in 14 days. The oral LD50 of N. oculata in rats was greater than 12 g/kg bw, and no toxicity effects were observed on biomass in terms of morbidity signs, plasma biochemical parameters, organ tissue, or body weight gain in response to N. oculata doses up to 12 g/kg rat bw. In the sub-chronic toxicity study, thirty-six Sprague-Dawley rats of both sexes were chosen and divided into three groups and provided with a diet containing 0, 3, and 6 g of N. oculata per kg bw, respectively, early every morning and then allowed free access to normal food and water ad libitum for 60 days. No biologically significant effects of N. Oculata on organ weights, male body weight gain, or on the plasma biochemical parameters were observed in either treatment group. However, low creatinine and significant differences in body weight gain by female rats were noted in the treatment groups. These changes were not considered as toxicologically significant. The no observable adverse effect level (NOAEL) for N. Oculata under the conditions of this study was 12 g/kg bw/day for acute toxicity and 6 g/kg bw/day for sub-chronic toxicity for both male and female rats. Academic Journals 2012-02-19 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24699/1/24699.pdf Kafaie, Soroush and Loh, Su Peng and Mohtarrudin, Norhafizah (2012) Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats. African Journal of Agricultural Research, 7 (7). art. no. CBB9DAF44826. pp. 1220-1225. ISSN 1991-637X http://www.academicjournals.org/journal/AJAR/article-abstract/CBB9DAF44826 10.5897/AJAR11.1793
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Putra Malaysia
building	UPM Institutional Repository
collection	Online Access
language	English
description	The aim of this study was to investigate the acute and sub-chronic toxicities of Nannochloropsis oculata biomass. In the acute toxicity study, twelve Sprague-Dawley rats of both sexes were gavaged with 12 g/kg body weight (bw) of N. oculata one time, and then tested for morbidity and mortality in 14 days. The oral LD50 of N. oculata in rats was greater than 12 g/kg bw, and no toxicity effects were observed on biomass in terms of morbidity signs, plasma biochemical parameters, organ tissue, or body weight gain in response to N. oculata doses up to 12 g/kg rat bw. In the sub-chronic toxicity study, thirty-six Sprague-Dawley rats of both sexes were chosen and divided into three groups and provided with a diet containing 0, 3, and 6 g of N. oculata per kg bw, respectively, early every morning and then allowed free access to normal food and water ad libitum for 60 days. No biologically significant effects of N. Oculata on organ weights, male body weight gain, or on the plasma biochemical parameters were observed in either treatment group. However, low creatinine and significant differences in body weight gain by female rats were noted in the treatment groups. These changes were not considered as toxicologically significant. The no observable adverse effect level (NOAEL) for N. Oculata under the conditions of this study was 12 g/kg bw/day for acute toxicity and 6 g/kg bw/day for sub-chronic toxicity for both male and female rats.
format	Article
author	Kafaie, Soroush Loh, Su Peng Mohtarrudin, Norhafizah
spellingShingle	Kafaie, Soroush Loh, Su Peng Mohtarrudin, Norhafizah Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
author_facet	Kafaie, Soroush Loh, Su Peng Mohtarrudin, Norhafizah
author_sort	Kafaie, Soroush
title	Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
title_short	Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
title_full	Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
title_fullStr	Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
title_full_unstemmed	Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats
title_sort	acute and sub-chronic toxicological assessment of nannochloropsis oculata in rats
publisher	Academic Journals
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/ http://psasir.upm.edu.my/id/eprint/24699/1/24699.pdf
first_indexed	2018-09-07T14:50:55Z
last_indexed	2018-09-07T14:50:55Z
_version_	1610960711561773056

Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats

Similar Items