Mechanism of Action of Camptothecin
Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo-...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
Annals of the New York Academy of Sciences
2006
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/8233/ http://ir.unimas.my/8233/ http://ir.unimas.my/8233/ |