Cyclin D1 expression in acral melanoma : a case control study in Sarawak

Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological m...

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Main Authors:	Zainal Abidin, Ibrahim, M Zulkarnaen, A Narihan, Dk Norlida, A Ojep, Ashley Edward Roy, Soosay, Kok Long, Pan
Format:	Article
Language:	English
Published:	Malaysian J Pathol 2012
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://ir.unimas.my/81/ http://ir.unimas.my/81/1/Cyclin%20D1%20expression%20in%20acral%20%28abstract%29.pdf

id	unimas-81
recordtype	eprints
spelling	unimas-812016-12-28T04:26:17Z http://ir.unimas.my/81/ Cyclin D1 expression in acral melanoma : a case control study in Sarawak Zainal Abidin, Ibrahim M Zulkarnaen, A Narihan Dk Norlida, A Ojep Ashley Edward Roy, Soosay Kok Long, Pan R Medicine (General) RB Pathology Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological material of malignant melanoma in the Sarawak General Hospital from year 2004 to 2010. 43 tumours, comprising 28 acral melanoma and 15 non-acral melanoma, had sufficient material to be included in the study. The majority (36%) of acral melanoma tumours occurred in the heel. The tumours were analyzed for cyclin D1 expression by immunohistochemistry. 68% of acral melanoma were cyclin D1 positive compared to a positivity of 33% in non-acral tumours. This difference was statistically significant (p < 0.05). This finding may improve the histological diagnosis of acral melanoma and detection of positive resection margins. Malaysian J Pathol 2012 Article PeerReviewed text en http://ir.unimas.my/81/1/Cyclin%20D1%20expression%20in%20acral%20%28abstract%29.pdf Zainal Abidin, Ibrahim and M Zulkarnaen, A Narihan and Dk Norlida, A Ojep and Ashley Edward Roy, Soosay and Kok Long, Pan (2012) Cyclin D1 expression in acral melanoma : a case control study in Sarawak. The Malaysian Journal Pathology, 34 (2). pp. 89-95.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Sarawak
building	UNIMAS Institutional Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Zainal Abidin, Ibrahim M Zulkarnaen, A Narihan Dk Norlida, A Ojep Ashley Edward Roy, Soosay Kok Long, Pan Cyclin D1 expression in acral melanoma : a case control study in Sarawak
description	Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological material of malignant melanoma in the Sarawak General Hospital from year 2004 to 2010. 43 tumours, comprising 28 acral melanoma and 15 non-acral melanoma, had sufficient material to be included in the study. The majority (36%) of acral melanoma tumours occurred in the heel. The tumours were analyzed for cyclin D1 expression by immunohistochemistry. 68% of acral melanoma were cyclin D1 positive compared to a positivity of 33% in non-acral tumours. This difference was statistically significant (p < 0.05). This finding may improve the histological diagnosis of acral melanoma and detection of positive resection margins.
format	Article
author	Zainal Abidin, Ibrahim M Zulkarnaen, A Narihan Dk Norlida, A Ojep Ashley Edward Roy, Soosay Kok Long, Pan
author_facet	Zainal Abidin, Ibrahim M Zulkarnaen, A Narihan Dk Norlida, A Ojep Ashley Edward Roy, Soosay Kok Long, Pan
author_sort	Zainal Abidin, Ibrahim
title	Cyclin D1 expression in acral melanoma : a case control study in Sarawak
title_short	Cyclin D1 expression in acral melanoma : a case control study in Sarawak
title_full	Cyclin D1 expression in acral melanoma : a case control study in Sarawak
title_fullStr	Cyclin D1 expression in acral melanoma : a case control study in Sarawak
title_full_unstemmed	Cyclin D1 expression in acral melanoma : a case control study in Sarawak
title_sort	cyclin d1 expression in acral melanoma : a case control study in sarawak
publisher	Malaysian J Pathol
publishDate	2012
url	http://ir.unimas.my/81/ http://ir.unimas.my/81/1/Cyclin%20D1%20expression%20in%20acral%20%28abstract%29.pdf
first_indexed	2018-09-06T00:15:06Z
last_indexed	2018-09-06T00:15:06Z
_version_	1610869047864328192

Cyclin D1 expression in acral melanoma : a case control study in Sarawak

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