Removal of endotoxins from plasmid DNA: analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA
Endotoxin lipopolysaccharide removal from plasmid DNA-based vaccine remains a very challenging task for bioprocess engineers. This paper examined the potential use and advantages of divalent cation (Zn(2+), Ca(2+), Mg(2+)) induced aggregation as a plasmid DNA purification method for lipopolysacchari...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley & Sons Ltd.
2012
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| Subjects: | |
| Online Access: | http://eprints.ums.edu.my/20417/ http://eprints.ums.edu.my/20417/ http://eprints.ums.edu.my/20417/1/Removal%20of%20endotoxins%20from%20plasmid%20DNA.pdf |