Effect of ribavirin on zidovudine efficacy and toxicity in vitro: A concentration-dependent interaction
Zidovudine (ZDV) is converted to its active triphosphate (ZDVTP) by intracellular kinases, The intermediate ZDV monophosphate (ZDVMP) is believed to play a major role in ZDV toxicity. Manipulation of ZDV phosphorylation is a possible therapeutic strategy for altering the risk-benefit ratio, Here we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
1998
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| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pubmed/9870320 http://www.ncbi.nlm.nih.gov/pubmed/9870320 |