Alpha-tocopherol nanodispersions: preparation, characterization and stability evaluation
A top down approach based on emulsification-evaporation technique was used to prepare nanodispersion of α-tocopherol. Physicochemical properties of the prepared nanodispersions were investigated under combination of the processing parameters (pressure and cycle) and ratio of aqueous:organic. Storag...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
2008
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/6878/ |
| Summary: | A top down approach based on emulsification-evaporation technique was used to prepare nanodispersion of α-tocopherol. Physicochemical properties of the prepared nanodispersions were investigated under combination of the processing parameters (pressure and cycle) and ratio of aqueous:organic. Storage study was performed for 3 months to evaluate the stability of all the prepared nanodispersions. The results showed that homogenization pressure have significant (P < 0.05) influence on the droplet diameter and size distribution. On the contrary, the processing cycle had not significant (P > 0.05) effect on the droplet diameter and size distribution of the prepared nanodispersion. Droplet diameters in the range of 90-120 nm were obtained for the prepared α-tocopherol nanodispersions. During storage duration, there were no significant (P > 0.05) changes in mean diameters while the concentrations of α-tocopherol were significantly (P < 0.05) reduced for all prepared nanodispersions. In general, it is shown that emulsification-evaporation technique can be used as a suitable technique for the production of α-tocopherol nanodispersions with narrow size distribution. |
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