NMDA receptor antagonism with novel indolyl, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy
N-methyl-D-aspartate receptors (NMDAR) play a central role in epileptogensis and NMDAR antagonists have been shown to have antiepileptic effects in animals and humans. Despite significant progress in the development of antiepileptic therapies over the previous 3 decades, a need still exists for nove...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Publishing Group
2017
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1038/srep45540 http://dx.doi.org/10.1038/srep45540 http://eprints.um.edu.my/19038/1/NMDA_receptor_antagonism_with_novel_indolyl.pdf |