VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction
Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K24...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier
2017
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1016/j.virol.2016.11.009 http://dx.doi.org/10.1016/j.virol.2016.11.009 |