Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats

Several plants are used in folk medicine to treat gastrointestinal disorders. Gynura procumbens is a medicinal plant commonly used in traditional treatment of many aliments. In this study, G. procumbens ethanolic leaf extract (GPELE) was used to investigate its gastroprotective effect in adult Sprag...

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Main Authors:	Mahmood, A.A., Mariod, A.A., Al-Bayaty, F., Abdel-Wahab, S.I.
Format:	Article
Published:	2010
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/14761/

id	um-14761
recordtype	eprints
spelling	um-147612015-11-13T08:19:20Z Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats Mahmood, A.A. Mariod, A.A. Al-Bayaty, F. Abdel-Wahab, S.I. R Medicine Several plants are used in folk medicine to treat gastrointestinal disorders. Gynura procumbens is a medicinal plant commonly used in traditional treatment of many aliments. In this study, G. procumbens ethanolic leaf extract (GPELE) was used to investigate its gastroprotective effect in adult Sprague dawley rats which were divided into six groups. The rats were orally pre-treated with carboxymethyl cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/ kg (reference group), 50, 100, 200 and 400 mg/ kg of GPELE in CMC solution (experimental groups), one hour before oral administration of absolute ethanol to generate gastric mucosal injury. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with GPELE exhibited significant protection of gastric mucosal injury. These findings were also confirmed by histological studies. Acute toxicity study with a higher dose of 5 g/ kg did not manifest any toxicological signs in rats. These results suggest that GPELE promotes ulcer protection as ascertained grossly by significant reduction of ulcer area, and histologically by comparatively decreases in ulcer areas, reduction or absence of edema and leucocytes infiltration of submucosal layer compared to ulcer control group. 2010 Article PeerReviewed Mahmood, A.A.; Mariod, A.A.; Al-Bayaty, F.; Abdel-Wahab, S.I. (2010) Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats. Journal of Medicinal Plants Research <http://eprints.um.edu.my/view/publication/Journal_of_Medicinal_Plants_Research.html>, 4 (8). pp. 685-691. http://eprints.um.edu.my/14761/
repository_type	Digital Repository
institution_category	Local University
institution	University Malaya
building	UM Research Repository
collection	Online Access
topic	R Medicine
spellingShingle	R Medicine Mahmood, A.A. Mariod, A.A. Al-Bayaty, F. Abdel-Wahab, S.I. Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
description	Several plants are used in folk medicine to treat gastrointestinal disorders. Gynura procumbens is a medicinal plant commonly used in traditional treatment of many aliments. In this study, G. procumbens ethanolic leaf extract (GPELE) was used to investigate its gastroprotective effect in adult Sprague dawley rats which were divided into six groups. The rats were orally pre-treated with carboxymethyl cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/ kg (reference group), 50, 100, 200 and 400 mg/ kg of GPELE in CMC solution (experimental groups), one hour before oral administration of absolute ethanol to generate gastric mucosal injury. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with GPELE exhibited significant protection of gastric mucosal injury. These findings were also confirmed by histological studies. Acute toxicity study with a higher dose of 5 g/ kg did not manifest any toxicological signs in rats. These results suggest that GPELE promotes ulcer protection as ascertained grossly by significant reduction of ulcer area, and histologically by comparatively decreases in ulcer areas, reduction or absence of edema and leucocytes infiltration of submucosal layer compared to ulcer control group.
format	Article
author	Mahmood, A.A. Mariod, A.A. Al-Bayaty, F. Abdel-Wahab, S.I.
author_facet	Mahmood, A.A. Mariod, A.A. Al-Bayaty, F. Abdel-Wahab, S.I.
author_sort	Mahmood, A.A.
title	Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
title_short	Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
title_full	Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
title_fullStr	Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
title_full_unstemmed	Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
title_sort	anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats
publishDate	2010
url	http://eprints.um.edu.my/14761/
first_indexed	2018-09-06T06:25:24Z
last_indexed	2018-09-06T06:25:24Z
_version_	1610838310226231296

Anti-ulcerogenic activity of gynura procumbens leaf extract against experimentally-induced gastric lesions in rats

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