Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats

Herbal medicines appeared promising in prevention of many diseases. This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol. Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive contro...

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Main Authors:	Rahim, N.A., Hassandarvish, P., Golbabapour, S., Ismail, S., Tayyab, S., Abdulla, M.A.
Format:	Article
Published:	Hindawi Publishing Corporation 2014
Subjects:	Q Science (General) QH Natural history
Online Access:	http://www.hindawi.com/journals/bmri/2014/416409/ http://www.hindawi.com/journals/bmri/2014/416409/

id	um-14519
recordtype	eprints
spelling	um-145192015-11-05T07:50:56Z Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats Rahim, N.A. Hassandarvish, P. Golbabapour, S. Ismail, S. Tayyab, S. Abdulla, M.A. Q Science (General) QH Natural history Herbal medicines appeared promising in prevention of many diseases. This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol. Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg and 500 mg/kg of the leaf extract, respectively. To induce of gastric ulcers formation, ethanol (5 mL/kg) was given orally to all groups except normal control. Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers. Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased. Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury. Furthermore, the leaf extract elevated the mucus weight, level of prostaglandin E2 and superoxide dismutase. The extract also reduced malondialdehyde amount significantly. Results showed leaf extract of Curcuma xanthorrhiza can enhanced the gastric protection and sustained the integrity of gastric mucosa structure. Acute toxicity test did not showed any sign of toxicity (2 g/kg and 5 g/kg). Hindawi Publishing Corporation 2014 Article PeerReviewed http://www.hindawi.com/journals/bmri/2014/416409/ Rahim, N.A.; Hassandarvish, P.; Golbabapour, S.; Ismail, S.; Tayyab, S.; Abdulla, M.A. (2014) Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International <http://eprints.um.edu.my/view/publication/BioMed_Research_International.html>, 2014. pp. 1-10. ISSN 2314-6133 http://eprints.um.edu.my/14519/
repository_type	Digital Repository
institution_category	Local University
institution	University Malaya
building	UM Research Repository
collection	Online Access
topic	Q Science (General) QH Natural history
spellingShingle	Q Science (General) QH Natural history Rahim, N.A. Hassandarvish, P. Golbabapour, S. Ismail, S. Tayyab, S. Abdulla, M.A. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
description	Herbal medicines appeared promising in prevention of many diseases. This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol. Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg and 500 mg/kg of the leaf extract, respectively. To induce of gastric ulcers formation, ethanol (5 mL/kg) was given orally to all groups except normal control. Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers. Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased. Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury. Furthermore, the leaf extract elevated the mucus weight, level of prostaglandin E2 and superoxide dismutase. The extract also reduced malondialdehyde amount significantly. Results showed leaf extract of Curcuma xanthorrhiza can enhanced the gastric protection and sustained the integrity of gastric mucosa structure. Acute toxicity test did not showed any sign of toxicity (2 g/kg and 5 g/kg).
format	Article
author	Rahim, N.A. Hassandarvish, P. Golbabapour, S. Ismail, S. Tayyab, S. Abdulla, M.A.
author_facet	Rahim, N.A. Hassandarvish, P. Golbabapour, S. Ismail, S. Tayyab, S. Abdulla, M.A.
author_sort	Rahim, N.A.
title	Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
title_short	Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
title_full	Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
title_fullStr	Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
title_full_unstemmed	Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
title_sort	gastroprotective effect of ethanolic extract of curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in sprague-dawley rats
publisher	Hindawi Publishing Corporation
publishDate	2014
url	http://www.hindawi.com/journals/bmri/2014/416409/ http://www.hindawi.com/journals/bmri/2014/416409/
first_indexed	2018-09-06T06:23:32Z
last_indexed	2018-09-06T06:23:32Z
_version_	1610838192850731008

Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats

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