The epstein-Barr virus and the pathogenesis of lymphoma

Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B...

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Main Authors:	Vockerodt, M., Yap, L.F., Shannon-Lowe, C., Curley, H., Wei, W.B., Vrzalikova, K., Murray, P.G.
Format:	Article
Published:	John Wiley & Sons 2015
Subjects:	RK Dentistry
Online Access:	http://www.ncbi.nlm.nih.gov/pubmed/25294567 http://www.ncbi.nlm.nih.gov/pubmed/25294567 http://eprints.um.edu.my/13556/1/epstein_barr.pdf

id	um-13556
recordtype	eprints
spelling	um-135562015-12-30T04:27:02Z The epstein-Barr virus and the pathogenesis of lymphoma Vockerodt, M. Yap, L.F. Shannon-Lowe, C. Curley, H. Wei, W.B. Vrzalikova, K. Murray, P.G. RK Dentistry Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas. However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus-host balance that exist between the different EBV-associated cancers. A further challenge is to identify the co-factors involved; because most persistently infected individuals will never develop an EBV-associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of EBV to lymphoma development. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. John Wiley & Sons 2015-01 Article PeerReviewed application/pdf http://eprints.um.edu.my/13556/1/epstein_barr.pdf http://www.ncbi.nlm.nih.gov/pubmed/25294567 Vockerodt, M.; Yap, L.F.; Shannon-Lowe, C.; Curley, H.; Wei, W.B.; Vrzalikova, K.; Murray, P.G. (2015) The epstein-Barr virus and the pathogenesis of lymphoma. The Journal of Pathology <http://eprints.um.edu.my/view/publication/The_Journal_of_Pathology.html>. ISSN 0022-3417 http://eprints.um.edu.my/13556/
repository_type	Digital Repository
institution_category	Local University
institution	University Malaya
building	UM Research Repository
collection	Online Access
topic	RK Dentistry
spellingShingle	RK Dentistry Vockerodt, M. Yap, L.F. Shannon-Lowe, C. Curley, H. Wei, W.B. Vrzalikova, K. Murray, P.G. The epstein-Barr virus and the pathogenesis of lymphoma
description	Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas. However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus-host balance that exist between the different EBV-associated cancers. A further challenge is to identify the co-factors involved; because most persistently infected individuals will never develop an EBV-associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of EBV to lymphoma development. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
format	Article
author	Vockerodt, M. Yap, L.F. Shannon-Lowe, C. Curley, H. Wei, W.B. Vrzalikova, K. Murray, P.G.
author_facet	Vockerodt, M. Yap, L.F. Shannon-Lowe, C. Curley, H. Wei, W.B. Vrzalikova, K. Murray, P.G.
author_sort	Vockerodt, M.
title	The epstein-Barr virus and the pathogenesis of lymphoma
title_short	The epstein-Barr virus and the pathogenesis of lymphoma
title_full	The epstein-Barr virus and the pathogenesis of lymphoma
title_fullStr	The epstein-Barr virus and the pathogenesis of lymphoma
title_full_unstemmed	The epstein-Barr virus and the pathogenesis of lymphoma
title_sort	epstein-barr virus and the pathogenesis of lymphoma
publisher	John Wiley & Sons
publishDate	2015
url	http://www.ncbi.nlm.nih.gov/pubmed/25294567 http://www.ncbi.nlm.nih.gov/pubmed/25294567 http://eprints.um.edu.my/13556/1/epstein_barr.pdf
first_indexed	2018-09-06T06:15:22Z
last_indexed	2018-09-06T06:15:22Z
_version_	1610837679127134208

The epstein-Barr virus and the pathogenesis of lymphoma

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