Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study

Aims: Reports from non-Asian populations indicate that painful physical symptoms (PPS) are associated with poorer clinical and functional outcomes in major depressive disorder (MDD). The purpose of this study is to report comparative changes in disease severity, treatment patterns and quality of lif...

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Main Authors:	Ang, Q.Q., Wing, Y.K., He, Y., Sulaiman, A., Chiu, N.Y., Shen, Y.C., Wang, G., Zhang, C., Lee, K.H., Singh, P., Granger, R.E., Raskin, J., Dossenbach, M.
Format:	Article
Published:	2009
Subjects:	BF Psychology R Medicine
Online Access:	http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2009.02107.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2009.02107.x/full

id	um-10982
recordtype	eprints
spelling	um-109822014-08-05T02:20:46Z Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study Ang, Q.Q. Wing, Y.K. He, Y. Sulaiman, A. Chiu, N.Y. Shen, Y.C. Wang, G. Zhang, C. Lee, K.H. Singh, P. Granger, R.E. Raskin, J. Dossenbach, M. BF Psychology R Medicine Aims: Reports from non-Asian populations indicate that painful physical symptoms (PPS) are associated with poorer clinical and functional outcomes in major depressive disorder (MDD). The purpose of this study is to report comparative changes in disease severity, treatment patterns and quality of life observed in East Asian patients with MDD, with and without PPS, as assessed prospectively over a 3-month observation period. Methods: This observational study enrolled 909 patients with MDD in psychiatric care settings in China, Hong Kong, Korea, Malaysia, Singapore and Taiwan. Patients were classified as PPS positive (PPS+) or negative (PPS)) based on mean modified Somatic Symptom Inventory scores of 2 or < 2 respectively. The Clinical Global Impression of Severity (CGI-S) and 17-item Hamilton Depression Rating Scale (HAMD(17)) determined depression severity; a visual analogue scale (VAS) determined pain severity; and the EuroQoL (EQ-5D) assessed well-being after 3 months observation. Results: Of the 909 enrolees, 355/471 (75.4) of PPS+ patients and 363/438 (82.9) of PPS) patients completed the study (p = 0.006). PPS+ patients improved less than PPS) patients on depression, pain and quality of life measures during the study (HAMD17 p < 0.001, CGI-S p < 0.001, VAS p = 0.008 and EQ-5D p = 0.004). Fewer PPS+ patients (46.5) achieved remission compared with PPS) patients (69.4, p < 0.001). Conclusion: As the presence of PPS is associated with poorer outcomes in East Asian MDD patients, clinical management should aim to address both the mental and PPS associated with MDD. 2009 Article PeerReviewed http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2009.02107.x/full Ang, Q.Q.; Wing, Y.K.; He, Y.; Sulaiman, A.; Chiu, N.Y.; Shen, Y.C.; Wang, G.; Zhang, C.; Lee, K.H.; Singh, P.; Granger, R.E.; Raskin, J.; Dossenbach, M. (2009) Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study. International Journal of Clinical Practice <http://eprints.um.edu.my/view/publication/International_Journal_of_Clinical_Practice.html>, 63 (7). pp. 1041-1049. ISSN 1368-5031 http://eprints.um.edu.my/10982/
repository_type	Digital Repository
institution_category	Local University
institution	University Malaya
building	UM Research Repository
collection	Online Access
topic	BF Psychology R Medicine
spellingShingle	BF Psychology R Medicine Ang, Q.Q. Wing, Y.K. He, Y. Sulaiman, A. Chiu, N.Y. Shen, Y.C. Wang, G. Zhang, C. Lee, K.H. Singh, P. Granger, R.E. Raskin, J. Dossenbach, M. Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
description	Aims: Reports from non-Asian populations indicate that painful physical symptoms (PPS) are associated with poorer clinical and functional outcomes in major depressive disorder (MDD). The purpose of this study is to report comparative changes in disease severity, treatment patterns and quality of life observed in East Asian patients with MDD, with and without PPS, as assessed prospectively over a 3-month observation period. Methods: This observational study enrolled 909 patients with MDD in psychiatric care settings in China, Hong Kong, Korea, Malaysia, Singapore and Taiwan. Patients were classified as PPS positive (PPS+) or negative (PPS)) based on mean modified Somatic Symptom Inventory scores of 2 or < 2 respectively. The Clinical Global Impression of Severity (CGI-S) and 17-item Hamilton Depression Rating Scale (HAMD(17)) determined depression severity; a visual analogue scale (VAS) determined pain severity; and the EuroQoL (EQ-5D) assessed well-being after 3 months observation. Results: Of the 909 enrolees, 355/471 (75.4) of PPS+ patients and 363/438 (82.9) of PPS) patients completed the study (p = 0.006). PPS+ patients improved less than PPS) patients on depression, pain and quality of life measures during the study (HAMD17 p < 0.001, CGI-S p < 0.001, VAS p = 0.008 and EQ-5D p = 0.004). Fewer PPS+ patients (46.5) achieved remission compared with PPS) patients (69.4, p < 0.001). Conclusion: As the presence of PPS is associated with poorer outcomes in East Asian MDD patients, clinical management should aim to address both the mental and PPS associated with MDD.
format	Article
author	Ang, Q.Q. Wing, Y.K. He, Y. Sulaiman, A. Chiu, N.Y. Shen, Y.C. Wang, G. Zhang, C. Lee, K.H. Singh, P. Granger, R.E. Raskin, J. Dossenbach, M.
author_facet	Ang, Q.Q. Wing, Y.K. He, Y. Sulaiman, A. Chiu, N.Y. Shen, Y.C. Wang, G. Zhang, C. Lee, K.H. Singh, P. Granger, R.E. Raskin, J. Dossenbach, M.
author_sort	Ang, Q.Q.
title	Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
title_short	Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
title_full	Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
title_fullStr	Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
title_full_unstemmed	Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study
title_sort	association between painful physical symptoms and clinical outcomes in east asian patients with major depressive disorder: a 3-month prospective observational study
publishDate	2009
url	http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2009.02107.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2009.02107.x/full
first_indexed	2018-09-06T05:54:45Z
last_indexed	2018-09-06T05:54:45Z
_version_	1610836381846732800

Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study

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