Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics

Although senescence is a defining property of euploid mammalian cells, its physiologic basis remains obscure. Previously, cell kinetics properties of normal tissue cells have not been considered in models for senescence. We now provide evidence that senescence is in fact the natural consequence of n...

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Bibliographic Details
Main Authors: Rambhatla, Lakshmi, Bohn, Shirley A, Stadler, Patrizia B, Boyd, Jonathan T, Coss, Ronald A, Sherley, James L
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79675/