Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear

Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area. In order to study periacetabular osteolysis, specialized software for computerized tomography (CT) scan...

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Main Authors:	Looney, R John, Boyd, Allen, Totterman, Saara, Seo, Gwy-Suk, Tamez-Pena, Jose, Campbell, Debbie, Novotny, Leonore, Olcott, Christopher, Martell, John, Hayes, F Ann, O'Keefe, Regis J, Schwarz, Edward M
Format:	Online
Language:	English
Published:	BioMed Central 2002
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64853/

id	pubmed-64853
recordtype	oai_dc
spelling	pubmed-648532002-01-25 Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear Looney, R John Boyd, Allen Totterman, Saara Seo, Gwy-Suk Tamez-Pena, Jose Campbell, Debbie Novotny, Leonore Olcott, Christopher Martell, John Hayes, F Ann O'Keefe, Regis J Schwarz, Edward M Research Article Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area. In order to study periacetabular osteolysis, specialized software for computerized tomography (CT) scan image analysis has been developed. This software (3D-CT) eliminates metal artifacts, allows three-dimensional segmentation of the CT image, and reconstructs the segmented image to provide an accurate representation and measurement of volume for osteolytic lesions. In the present study, 20 patients underwent periacetabular osteolytic volume determination using 3D-CT, functional assessment (using the Harris Hip Scale, the Western Ontario and McMaster University Osteoarthritis Index, and the short form 36 questionnaire), and two-dimensional analysis of volumetic polyethylene wear using digitalized plain films. Periacetabular osteolysis correlated directly with the polyethylene wear rate (relative risk [RR] = 0.494, P = 0.027). If one patient with an acetabular revision, one patient with recurrent dislocation, and one patient with a Biomet prosthesis are excluded, then the correlation between wear and osteolysis is improved (RR = 0.685, P = 0.002). In summary, the current study demonstrates both the feasibility of CT imaging of periacetabular osteolysis and the correlation between polyethylene wear and osteolytic volume, providing a potential outcome measure for clinical trials that are designed to examine interventions in this complex disease process. BioMed Central 2002 2001-10-03 /pmc/articles/PMC64853/ /pubmed/11879538 Text en Copyright © 2001 Looney et al, licensee BioMed Central Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Looney, R John Boyd, Allen Totterman, Saara Seo, Gwy-Suk Tamez-Pena, Jose Campbell, Debbie Novotny, Leonore Olcott, Christopher Martell, John Hayes, F Ann O'Keefe, Regis J Schwarz, Edward M
spellingShingle	Looney, R John Boyd, Allen Totterman, Saara Seo, Gwy-Suk Tamez-Pena, Jose Campbell, Debbie Novotny, Leonore Olcott, Christopher Martell, John Hayes, F Ann O'Keefe, Regis J Schwarz, Edward M Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
author_facet	Looney, R John Boyd, Allen Totterman, Saara Seo, Gwy-Suk Tamez-Pena, Jose Campbell, Debbie Novotny, Leonore Olcott, Christopher Martell, John Hayes, F Ann O'Keefe, Regis J Schwarz, Edward M
author_sort	Looney, R John
title	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
title_short	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
title_full	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
title_fullStr	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
title_full_unstemmed	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
title_sort	volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
description	Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area. In order to study periacetabular osteolysis, specialized software for computerized tomography (CT) scan image analysis has been developed. This software (3D-CT) eliminates metal artifacts, allows three-dimensional segmentation of the CT image, and reconstructs the segmented image to provide an accurate representation and measurement of volume for osteolytic lesions. In the present study, 20 patients underwent periacetabular osteolytic volume determination using 3D-CT, functional assessment (using the Harris Hip Scale, the Western Ontario and McMaster University Osteoarthritis Index, and the short form 36 questionnaire), and two-dimensional analysis of volumetic polyethylene wear using digitalized plain films. Periacetabular osteolysis correlated directly with the polyethylene wear rate (relative risk [RR] = 0.494, P = 0.027). If one patient with an acetabular revision, one patient with recurrent dislocation, and one patient with a Biomet prosthesis are excluded, then the correlation between wear and osteolysis is improved (RR = 0.685, P = 0.002). In summary, the current study demonstrates both the feasibility of CT imaging of periacetabular osteolysis and the correlation between polyethylene wear and osteolytic volume, providing a potential outcome measure for clinical trials that are designed to examine interventions in this complex disease process.
publisher	BioMed Central
publishDate	2002
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64853/
_version_	1611365365517910016

Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear

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