Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature

Because angiogenesis plays a major role in the perpetuation of inflammatory arthritis, we explored a method for selectively targeting and destroying new synovial blood vessels. Mice with collagen-induced arthritis were injected intravenously with phage expressing an RGD motif. In addition, the RGD p...

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Bibliographic Details
Main Authors: Gerlag, Danielle M, Borges, Eric, Tak, Paul P, Ellerby, H Michael, Bredesen, Dale E, Pasqualini, Renata, Ruoslahti, Erkki, Firestein, Gary S
Format: Online
Language:English
Published: BioMed Central 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64846/