Tumor necrosis factor-α and muscle wasting: a cellular perspective
Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of culture...
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| Format: | Online |
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BioMed Central
2001
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59514/ |
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pubmed-59514 |
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pubmed-595142001-11-06 Tumor necrosis factor-α and muscle wasting: a cellular perspective Reid, Michael B Li, Yi-Ping Commentary Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action. BioMed Central 2001 2001-07-12 /pmc/articles/PMC59514/ /pubmed/11686894 http://dx.doi.org/10.1186/rr67 Text en Copyright © 2001 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Reid, Michael B Li, Yi-Ping |
| spellingShingle |
Reid, Michael B Li, Yi-Ping Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| author_facet |
Reid, Michael B Li, Yi-Ping |
| author_sort |
Reid, Michael B |
| title |
Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| title_short |
Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| title_full |
Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| title_fullStr |
Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| title_full_unstemmed |
Tumor necrosis factor-α and muscle wasting: a cellular perspective |
| title_sort |
tumor necrosis factor-α and muscle wasting: a cellular perspective |
| description |
Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action. |
| publisher |
BioMed Central |
| publishDate |
2001 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59514/ |
| _version_ |
1611365126280052736 |