EMSY links breast cancer gene 2 to the 'Royal Family'
Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the...
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| Format: | Online |
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BioMed Central
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549177/ |
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pubmed-549177 |
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pubmed-5491772005-02-19 EMSY links breast cancer gene 2 to the 'Royal Family' Yao, Jun Polyak, Kornelia Commentary Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the BRCA2 pathway in sporadic tumors. Furthermore, EMSY's binding to members of the 'Royal Family' of chromatin remodeling proteins may lead to a better understanding of the physiological function of BRCA2 and its role in chromatin remodeling. BioMed Central 2004 2004-07-19 /pmc/articles/PMC549177/ /pubmed/15318925 http://dx.doi.org/10.1186/bcr916 Text en Copyright © 2004 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yao, Jun Polyak, Kornelia |
| spellingShingle |
Yao, Jun Polyak, Kornelia EMSY links breast cancer gene 2 to the 'Royal Family' |
| author_facet |
Yao, Jun Polyak, Kornelia |
| author_sort |
Yao, Jun |
| title |
EMSY links breast cancer gene 2 to the 'Royal Family' |
| title_short |
EMSY links breast cancer gene 2 to the 'Royal Family' |
| title_full |
EMSY links breast cancer gene 2 to the 'Royal Family' |
| title_fullStr |
EMSY links breast cancer gene 2 to the 'Royal Family' |
| title_full_unstemmed |
EMSY links breast cancer gene 2 to the 'Royal Family' |
| title_sort |
emsy links breast cancer gene 2 to the 'royal family' |
| description |
Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the BRCA2 pathway in sporadic tumors. Furthermore, EMSY's binding to members of the 'Royal Family' of chromatin remodeling proteins may lead to a better understanding of the physiological function of BRCA2 and its role in chromatin remodeling. |
| publisher |
BioMed Central |
| publishDate |
2004 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549177/ |
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1611370937971638272 |