The Universal Protein Resource (UniProt)

The Universal Protein Resource (UniProt)

The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. Formed by uniting the Swiss-Prot, TrEMBL and PIR protein database activities, the UniProt consortium produces three layers o...

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Main Authors: Bairoch, Amos, Apweiler, Rolf, Wu, Cathy H., Barker, Winona C., Boeckmann, Brigitte, Ferro, Serenella, Gasteiger, Elisabeth, Huang, Hongzhan, Lopez, Rodrigo, Magrane, Michele, Martin, Maria J., Natale, Darren A., O'Donovan, Claire, Redaschi, Nicole, Yeh, Lai-Su L.
Format: Online
Language:English
Published: Oxford University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540024/
id pubmed-540024
recordtype oai_dc
spelling pubmed-5400242005-01-04 The Universal Protein Resource (UniProt) Bairoch, Amos Apweiler, Rolf Wu, Cathy H. Barker, Winona C. Boeckmann, Brigitte Ferro, Serenella Gasteiger, Elisabeth Huang, Hongzhan Lopez, Rodrigo Magrane, Michele Martin, Maria J. Natale, Darren A. O'Donovan, Claire Redaschi, Nicole Yeh, Lai-Su L. Articles The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. Formed by uniting the Swiss-Prot, TrEMBL and PIR protein database activities, the UniProt consortium produces three layers of protein sequence databases: the UniProt Archive (UniParc), the UniProt Knowledgebase (UniProt) and the UniProt Reference (UniRef) databases. The UniProt Knowledgebase is a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase with extensive cross-references. This centrepiece consists of two sections: UniProt/Swiss-Prot, with fully, manually curated entries; and UniProt/TrEMBL, enriched with automated classification and annotation. During 2004, tens of thousands of Knowledgebase records got manually annotated or updated; we introduced a new comment line topic: TOXIC DOSE to store information on the acute toxicity of a toxin; the UniProt keyword list got augmented by additional keywords; we improved the documentation of the keywords and are continuously overhauling and standardizing the annotation of post-translational modifications. Furthermore, we introduced a new documentation file of the strains and their synonyms. Many new database cross-references were introduced and we started to make use of Digital Object Identifiers. We also achieved in collaboration with the Macromolecular Structure Database group at EBI an improved integration with structural databases by residue level mapping of sequences from the Protein Data Bank entries onto corresponding UniProt entries. For convenient sequence searches we provide the UniRef non-redundant sequence databases. The comprehensive UniParc database stores the complete body of publicly available protein sequence data. The UniProt databases can be accessed online (http://www.uniprot.org) or downloaded in several formats (ftp://ftp.uniprot.org/pub). New releases are published every two weeks. Oxford University Press 2005-01-01 2004-12-17 /pmc/articles/PMC540024/ /pubmed/15608167 http://dx.doi.org/10.1093/nar/gki070 Text en Copyright © 2005 Oxford University Press
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Bairoch, Amos
Apweiler, Rolf
Wu, Cathy H.
Barker, Winona C.
Boeckmann, Brigitte
Ferro, Serenella
Gasteiger, Elisabeth
Huang, Hongzhan
Lopez, Rodrigo
Magrane, Michele
Martin, Maria J.
Natale, Darren A.
O'Donovan, Claire
Redaschi, Nicole
Yeh, Lai-Su L.
spellingShingle Bairoch, Amos
Apweiler, Rolf
Wu, Cathy H.
Barker, Winona C.
Boeckmann, Brigitte
Ferro, Serenella
Gasteiger, Elisabeth
Huang, Hongzhan
Lopez, Rodrigo
Magrane, Michele
Martin, Maria J.
Natale, Darren A.
O'Donovan, Claire
Redaschi, Nicole
Yeh, Lai-Su L.
The Universal Protein Resource (UniProt)
author_facet Bairoch, Amos
Apweiler, Rolf
Wu, Cathy H.
Barker, Winona C.
Boeckmann, Brigitte
Ferro, Serenella
Gasteiger, Elisabeth
Huang, Hongzhan
Lopez, Rodrigo
Magrane, Michele
Martin, Maria J.
Natale, Darren A.
O'Donovan, Claire
Redaschi, Nicole
Yeh, Lai-Su L.
author_sort Bairoch, Amos
title The Universal Protein Resource (UniProt)
title_short The Universal Protein Resource (UniProt)
title_full The Universal Protein Resource (UniProt)
title_fullStr The Universal Protein Resource (UniProt)
title_full_unstemmed The Universal Protein Resource (UniProt)
title_sort universal protein resource (uniprot)
description The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. Formed by uniting the Swiss-Prot, TrEMBL and PIR protein database activities, the UniProt consortium produces three layers of protein sequence databases: the UniProt Archive (UniParc), the UniProt Knowledgebase (UniProt) and the UniProt Reference (UniRef) databases. The UniProt Knowledgebase is a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase with extensive cross-references. This centrepiece consists of two sections: UniProt/Swiss-Prot, with fully, manually curated entries; and UniProt/TrEMBL, enriched with automated classification and annotation. During 2004, tens of thousands of Knowledgebase records got manually annotated or updated; we introduced a new comment line topic: TOXIC DOSE to store information on the acute toxicity of a toxin; the UniProt keyword list got augmented by additional keywords; we improved the documentation of the keywords and are continuously overhauling and standardizing the annotation of post-translational modifications. Furthermore, we introduced a new documentation file of the strains and their synonyms. Many new database cross-references were introduced and we started to make use of Digital Object Identifiers. We also achieved in collaboration with the Macromolecular Structure Database group at EBI an improved integration with structural databases by residue level mapping of sequences from the Protein Data Bank entries onto corresponding UniProt entries. For convenient sequence searches we provide the UniRef non-redundant sequence databases. The comprehensive UniParc database stores the complete body of publicly available protein sequence data. The UniProt databases can be accessed online (http://www.uniprot.org) or downloaded in several formats (ftp://ftp.uniprot.org/pub). New releases are published every two weeks.
publisher Oxford University Press
publishDate 2005
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540024/
_version_ 1611370266065108992

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