The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World

The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World

West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV s...

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Main Authors: Lucas, Marianne, Frenkiel, Marie-Pascale, Mashimo, Tomoji, Guénet, Jean-Louis, Deubel, Vincent, Desprès, Philippe, Ceccaldi, Pierre-Emmanuel
Format: Online
Language:English
Published: BioMed Central 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535539/
id pubmed-535539
recordtype oai_dc
spelling pubmed-5355392004-12-12 The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World Lucas, Marianne Frenkiel, Marie-Pascale Mashimo, Tomoji Guénet, Jean-Louis Deubel, Vincent Desprès, Philippe Ceccaldi, Pierre-Emmanuel Short Report West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causing neuronal death. These results demonstrate that Israeli strain IS-98-ST1 provides a suitable viral model for WNV-induced disease associated with recent WNV outbreaks in the Old World. BioMed Central 2004-11-18 /pmc/articles/PMC535539/ /pubmed/15550172 http://dx.doi.org/10.1186/1743-422X-1-9 Text en Copyright © 2004 Lucas et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lucas, Marianne
Frenkiel, Marie-Pascale
Mashimo, Tomoji
Guénet, Jean-Louis
Deubel, Vincent
Desprès, Philippe
Ceccaldi, Pierre-Emmanuel
spellingShingle Lucas, Marianne
Frenkiel, Marie-Pascale
Mashimo, Tomoji
Guénet, Jean-Louis
Deubel, Vincent
Desprès, Philippe
Ceccaldi, Pierre-Emmanuel
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
author_facet Lucas, Marianne
Frenkiel, Marie-Pascale
Mashimo, Tomoji
Guénet, Jean-Louis
Deubel, Vincent
Desprès, Philippe
Ceccaldi, Pierre-Emmanuel
author_sort Lucas, Marianne
title The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
title_short The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
title_full The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
title_fullStr The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
title_full_unstemmed The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World
title_sort israeli strain is-98-st1 of west nile virus as viral model for west nile encephalitis in the old world
description West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causing neuronal death. These results demonstrate that Israeli strain IS-98-ST1 provides a suitable viral model for WNV-induced disease associated with recent WNV outbreaks in the Old World.
publisher BioMed Central
publishDate 2004
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535539/
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