A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management

The delivery of implantable cardioverter defibrillator (ICD) therapy is sophisticated and requires the programming of over 100 settings. Physicians tailor these settings with the intention of optimizing ICD therapeutic efficacy, but the usefulness of this approach has not been studied and is unknown...

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Main Authors:	Morgan, John M, Sterns, Laurence D, Hanson, Jodi L, Ousdigian, Kevin T, Otterness, Mary F, Wilkoff, Bruce L
Format:	Online
Language:	English
Published:	BioMed Central 2004
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535530/

id	pubmed-535530
recordtype	oai_dc
spelling	pubmed-5355302004-12-12 A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management Morgan, John M Sterns, Laurence D Hanson, Jodi L Ousdigian, Kevin T Otterness, Mary F Wilkoff, Bruce L Review The delivery of implantable cardioverter defibrillator (ICD) therapy is sophisticated and requires the programming of over 100 settings. Physicians tailor these settings with the intention of optimizing ICD therapeutic efficacy, but the usefulness of this approach has not been studied and is unknown. Empiric programming of settings such as anti-tachycardia pacing (ATP) has been demonstrated to be effective, but an empiric approach to programming all VT/VF detection and therapy settings has not been studied. A single standardized empiric programming regimen was developed based on key strategies with the intention of restricting shock delivery to circumstances when it is the only effective and appropriate therapy. The EMPIRIC trial is a worldwide, multi-center, prospective, one-to-one randomized comparison of empiric to physician tailored programming for VT/VF detection and therapy in a broad group of about 900 dual chamber ICD patients. The trial will provide a better understanding of how particular programming strategies impact the quantity of shocks delivered and facilitate optimization of complex ICD programming. BioMed Central 2004 2004-11-12 /pmc/articles/PMC535530/ /pubmed/15541169 http://dx.doi.org/10.1186/1468-6708-5-12 Text en Copyright © 2004 Morgan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Morgan, John M Sterns, Laurence D Hanson, Jodi L Ousdigian, Kevin T Otterness, Mary F Wilkoff, Bruce L
spellingShingle	Morgan, John M Sterns, Laurence D Hanson, Jodi L Ousdigian, Kevin T Otterness, Mary F Wilkoff, Bruce L A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
author_facet	Morgan, John M Sterns, Laurence D Hanson, Jodi L Ousdigian, Kevin T Otterness, Mary F Wilkoff, Bruce L
author_sort	Morgan, John M
title	A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
title_short	A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
title_full	A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
title_fullStr	A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
title_full_unstemmed	A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
title_sort	trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management
description	The delivery of implantable cardioverter defibrillator (ICD) therapy is sophisticated and requires the programming of over 100 settings. Physicians tailor these settings with the intention of optimizing ICD therapeutic efficacy, but the usefulness of this approach has not been studied and is unknown. Empiric programming of settings such as anti-tachycardia pacing (ATP) has been demonstrated to be effective, but an empiric approach to programming all VT/VF detection and therapy settings has not been studied. A single standardized empiric programming regimen was developed based on key strategies with the intention of restricting shock delivery to circumstances when it is the only effective and appropriate therapy. The EMPIRIC trial is a worldwide, multi-center, prospective, one-to-one randomized comparison of empiric to physician tailored programming for VT/VF detection and therapy in a broad group of about 900 dual chamber ICD patients. The trial will provide a better understanding of how particular programming strategies impact the quantity of shocks delivered and facilitate optimization of complex ICD programming.
publisher	BioMed Central
publishDate	2004
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535530/
_version_	1611370033332617216

A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management

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