Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview

In Barrett’s esophagus, normal squamous epithelium is replaced by a metaplastic columnar epithelium as a consequence of chronic gastroesophageal reflux disease. There is a strong association with esophageal adenocarcinoma. In view of the increasing incidence of esophageal adenocarcinoma in the weste...

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Main Authors:	Schoofs, Nele, Bisschops, Raf, Prenen, Hans
Format:	Online
Language:	English
Published:	Hellenic Society of Gastroenterology 2017
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198232/

id	pubmed-5198232
recordtype	oai_dc
spelling	pubmed-51982322017-01-01 Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview Schoofs, Nele Bisschops, Raf Prenen, Hans Invited Review In Barrett’s esophagus, normal squamous epithelium is replaced by a metaplastic columnar epithelium as a consequence of chronic gastroesophageal reflux disease. There is a strong association with esophageal adenocarcinoma. In view of the increasing incidence of esophageal adenocarcinoma in the western world, it is important that more attention be paid to the progression of Barrett’s esophagus toward esophageal adenocarcinoma. Recently, several molecular factors have been identified that contribute to the sequence towards adenocarcinoma. This might help identify patients at risk and detect new targets for the prevention and treatment of esophageal adenocarcinoma in the future. Hellenic Society of Gastroenterology 2017 2016-09-30 /pmc/articles/PMC5198232/ /pubmed/28042232 http://dx.doi.org/10.20524/aog.2016.0091 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Schoofs, Nele Bisschops, Raf Prenen, Hans
spellingShingle	Schoofs, Nele Bisschops, Raf Prenen, Hans Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
author_facet	Schoofs, Nele Bisschops, Raf Prenen, Hans
author_sort	Schoofs, Nele
title	Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
title_short	Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
title_full	Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
title_fullStr	Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
title_full_unstemmed	Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
title_sort	progression of barrett’s esophagus toward esophageal adenocarcinoma: an overview
description	In Barrett’s esophagus, normal squamous epithelium is replaced by a metaplastic columnar epithelium as a consequence of chronic gastroesophageal reflux disease. There is a strong association with esophageal adenocarcinoma. In view of the increasing incidence of esophageal adenocarcinoma in the western world, it is important that more attention be paid to the progression of Barrett’s esophagus toward esophageal adenocarcinoma. Recently, several molecular factors have been identified that contribute to the sequence towards adenocarcinoma. This might help identify patients at risk and detect new targets for the prevention and treatment of esophageal adenocarcinoma in the future.
publisher	Hellenic Society of Gastroenterology
publishDate	2017
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198232/
_version_	1613843619349790720

Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview

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