Repair of DNA Double-Strand Breaks in Heterochromatin
DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the natur...
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| Format: | Online |
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MDPI
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197957/ |
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pubmed-51979572017-01-04 Repair of DNA Double-Strand Breaks in Heterochromatin Watts, Felicity Z. Review DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or the position of the break within the chromatin. In eukaryotic cells, nuclear DNA is maintained as either euchromatin (EC) which is loosely packed, or in a denser form, much of which is heterochromatin (HC). Due to the less accessible nature of the DNA in HC as compared to that in EC, repair of damage in HC is not as straightforward as repair in EC. Here we review the literature on how cells deal with DSBs in HC. MDPI 2016-12-16 /pmc/articles/PMC5197957/ /pubmed/27999260 http://dx.doi.org/10.3390/biom6040047 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Watts, Felicity Z. |
| spellingShingle |
Watts, Felicity Z. Repair of DNA Double-Strand Breaks in Heterochromatin |
| author_facet |
Watts, Felicity Z. |
| author_sort |
Watts, Felicity Z. |
| title |
Repair of DNA Double-Strand Breaks in Heterochromatin |
| title_short |
Repair of DNA Double-Strand Breaks in Heterochromatin |
| title_full |
Repair of DNA Double-Strand Breaks in Heterochromatin |
| title_fullStr |
Repair of DNA Double-Strand Breaks in Heterochromatin |
| title_full_unstemmed |
Repair of DNA Double-Strand Breaks in Heterochromatin |
| title_sort |
repair of dna double-strand breaks in heterochromatin |
| description |
DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or the position of the break within the chromatin. In eukaryotic cells, nuclear DNA is maintained as either euchromatin (EC) which is loosely packed, or in a denser form, much of which is heterochromatin (HC). Due to the less accessible nature of the DNA in HC as compared to that in EC, repair of damage in HC is not as straightforward as repair in EC. Here we review the literature on how cells deal with DSBs in HC. |
| publisher |
MDPI |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197957/ |
| _version_ |
1613843107104686080 |