Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
The blood-brain barrier (BBB) is an obstacle for antibody passage into the brain, impeding the development of immunotherapy and antibody-based diagnostics for brain disorders. In the present study, we have developed a brain shuttle for active transport of antibodies across the BBB by receptor-mediat...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2017
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197066/ |