Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction

Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction

Hypoxia-inducible factor 1α (HIF-1α) plays a critical protective role in ischemic heart disease. Under normoxic conditions, HIF-1α was degraded by oxygen-dependent prolyl hydroxylase-2 (PHD2). Gene therapy has become a promising strategy to inhibit the degradation of HIF-1α and to improve cardiac fu...

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Bibliographic Details
Main Authors: Zhang, Li, Sun, Zhenxing, Ren, Pingping, You, Manjie, Zhang, Jing, Fang, Lingyun, Wang, Jing, Chen, Yihan, Yan, Fei, Zheng, Hairong, Xie, Mingxing
Format: Online
Language:English
Published: Ivyspring International Publisher 2017
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196885/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196885/

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