Regulatory T Cells in Hepatitis B and C Virus Infections
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4+CD25+...
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The Korean Association of Immunologists
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195842/ |
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pubmed-5195842 |
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pubmed-51958422016-12-29 Regulatory T Cells in Hepatitis B and C Virus Infections Jung, Min Kyung Shin, Eui-Cheol Review Article Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4+CD25+Foxp3+ Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections. The Korean Association of Immunologists 2016-12 2016-12-22 /pmc/articles/PMC5195842/ /pubmed/28035208 http://dx.doi.org/10.4110/in.2016.16.6.330 Text en Copyright © 2016 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jung, Min Kyung Shin, Eui-Cheol |
| spellingShingle |
Jung, Min Kyung Shin, Eui-Cheol Regulatory T Cells in Hepatitis B and C Virus Infections |
| author_facet |
Jung, Min Kyung Shin, Eui-Cheol |
| author_sort |
Jung, Min Kyung |
| title |
Regulatory T Cells in Hepatitis B and C Virus Infections |
| title_short |
Regulatory T Cells in Hepatitis B and C Virus Infections |
| title_full |
Regulatory T Cells in Hepatitis B and C Virus Infections |
| title_fullStr |
Regulatory T Cells in Hepatitis B and C Virus Infections |
| title_full_unstemmed |
Regulatory T Cells in Hepatitis B and C Virus Infections |
| title_sort |
regulatory t cells in hepatitis b and c virus infections |
| description |
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4+CD25+Foxp3+ Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections. |
| publisher |
The Korean Association of Immunologists |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195842/ |
| _version_ |
1613839658194567168 |