Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials

There remain liver-related safety concerns, regarding potential hepatotoxicity in humans, induced by green tea intake, despite being supposedly beneficial. Although many randomized controlled trials (RCTs) of green tea extracts have been reported in the literature, the systematic reviews published t...

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Main Authors:	Isomura, T, Suzuki, S, Origasa, H, Hosono, A, Suzuki, M, Sawada, T, Terao, S, Muto, Y, Koga, T
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193539/

id	pubmed-5193539
recordtype	oai_dc
spelling	pubmed-51935392017-01-18 Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials Isomura, T Suzuki, S Origasa, H Hosono, A Suzuki, M Sawada, T Terao, S Muto, Y Koga, T Review There remain liver-related safety concerns, regarding potential hepatotoxicity in humans, induced by green tea intake, despite being supposedly beneficial. Although many randomized controlled trials (RCTs) of green tea extracts have been reported in the literature, the systematic reviews published to date were only based on subjective assessment of case reports. To more objectively examine the liver-related safety of green tea intake, we conducted a systematic review of published RCTs. A systematic literature search was conducted using three databases (PubMed, EMBASE and Cochrane Central Register of Controlled Trials) in December 2013 to identify RCTs of green tea extracts. Data on liver-related adverse events, including laboratory test abnormalities, were abstracted from the identified articles. Methodological quality of RCTs was assessed. After excluding duplicates, 561 titles and abstracts and 119 full-text articles were screened, and finally 34 trials were identified. Of these, liver-related adverse events were reported in four trials; these adverse events involved seven subjects (eight events) in the green tea intervention group and one subject (one event) in the control group. The summary odds ratio, estimated using a meta-analysis method for sparse event data, for intervention compared with placebo was 2.1 (95% confidence interval: 0.5–9.8). The few events reported in both groups were elevations of liver enzymes. Most were mild, and no serious liver-related adverse events were reported. Results of this review, although not conclusive, suggest that liver-related adverse events after intake of green tea extracts are expected to be rare. Nature Publishing Group 2016-11 2016-05-18 /pmc/articles/PMC5193539/ /pubmed/27188915 http://dx.doi.org/10.1038/ejcn.2016.78 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Isomura, T Suzuki, S Origasa, H Hosono, A Suzuki, M Sawada, T Terao, S Muto, Y Koga, T
spellingShingle	Isomura, T Suzuki, S Origasa, H Hosono, A Suzuki, M Sawada, T Terao, S Muto, Y Koga, T Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
author_facet	Isomura, T Suzuki, S Origasa, H Hosono, A Suzuki, M Sawada, T Terao, S Muto, Y Koga, T
author_sort	Isomura, T
title	Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
title_short	Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
title_full	Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
title_fullStr	Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
title_full_unstemmed	Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
title_sort	liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials
description	There remain liver-related safety concerns, regarding potential hepatotoxicity in humans, induced by green tea intake, despite being supposedly beneficial. Although many randomized controlled trials (RCTs) of green tea extracts have been reported in the literature, the systematic reviews published to date were only based on subjective assessment of case reports. To more objectively examine the liver-related safety of green tea intake, we conducted a systematic review of published RCTs. A systematic literature search was conducted using three databases (PubMed, EMBASE and Cochrane Central Register of Controlled Trials) in December 2013 to identify RCTs of green tea extracts. Data on liver-related adverse events, including laboratory test abnormalities, were abstracted from the identified articles. Methodological quality of RCTs was assessed. After excluding duplicates, 561 titles and abstracts and 119 full-text articles were screened, and finally 34 trials were identified. Of these, liver-related adverse events were reported in four trials; these adverse events involved seven subjects (eight events) in the green tea intervention group and one subject (one event) in the control group. The summary odds ratio, estimated using a meta-analysis method for sparse event data, for intervention compared with placebo was 2.1 (95% confidence interval: 0.5–9.8). The few events reported in both groups were elevations of liver enzymes. Most were mild, and no serious liver-related adverse events were reported. Results of this review, although not conclusive, suggest that liver-related adverse events after intake of green tea extracts are expected to be rare.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193539/
_version_	1613835441699553280

Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials

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