An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methy...

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Bibliographic Details
Main Authors: Svensson, Kjell A., Heinz, Beverly A., Schaus, John M., Beck, James P., Hao, Junliang, Krushinski, Joseph H., Reinhard, Matthew R., Cohen, Michael P., Hellman, Sarah L., Getman, Brian G., Wang, Xushan, Menezes, Michelle M., Maren, Deanna L., Falcone, Julie F., Anderson, Wesley H., Wright, Rebecca A., Morin, S. Michelle, Knopp, Kelly L., Adams, Benjamin L., Rogovoy, Borys, Okun, Ilya, Suter, Todd M., Statnick, Michael A., Gehlert, Donald R., Nelson, David L., Lucaites, Virginia L., Emkey, Renee, DeLapp, Neil W., Wiernicki, Todd R., Cramer, Jeffrey W., Yang, Charles R., Bruns, Robert F.
Format: Online
Language:English
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193077/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193077/

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