Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases. The pharmacological depletion of senescent cells (SCs) with a “senolytic agent”, a small molecule that selectively kills SCs, is a potential novel therapeutic approach for these diseases. Rec...

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Bibliographic Details
Main Authors: Wang, Yingying, Chang, Jianhui, Liu, Xingui, Zhang, Xuan, Zhang, Suping, Zhang, Xin, Zhou, Daohong, Zheng, Guangrong
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191878/