Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analy...

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Bibliographic Details
Main Authors: Richard, Angélique, Boullu, Loïs, Herbach, Ulysse, Bonnafoux, Arnaud, Morin, Valérie, Vallin, Elodie, Guillemin, Anissa, Papili Gao, Nan, Gunawan, Rudiyanto, Cosette, Jérémie, Arnaud, Ophélie, Kupiec, Jean-Jacques, Espinasse, Thibault, Gonin-Giraud, Sandrine, Gandrillon, Olivier
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191835/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191835/

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