Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer

Gastric cancer is a prevalent tumor that is usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated sign...

Full description

Bibliographic Details
Main Authors:	Han, Shiwei, Ma, Xuemei, Zhao, Yanxia, Zhao, Hongying, Batista, Ana, Zhou, Sheng, Zhou, Xiaona, Yang, Yao, Wang, Tingting, Bi, Jingtao, Xia, Zheng, Bai, Zhigang, Garkavtsev, Igor, Zhang, Zhongtao
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190106/

id	pubmed-5190106
recordtype	oai_dc
spelling	pubmed-51901062017-01-05 Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer Han, Shiwei Ma, Xuemei Zhao, Yanxia Zhao, Hongying Batista, Ana Zhou, Sheng Zhou, Xiaona Yang, Yao Wang, Tingting Bi, Jingtao Xia, Zheng Bai, Zhigang Garkavtsev, Igor Zhang, Zhongtao Research Paper Gastric cancer is a prevalent tumor that is usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell carcinomas. We demonstrate that loss of GPC3 correlates with poor overall survival in patients. Moreover, we show that absence of GPC3 causes up-regulation of MAPK/FoxM1 signaling and that blockade of this pathway alters cellular invasion. An inverse correlation between GPC3 and FoxM1 is also shown in patient samples. These data identify GPC3 as a potential metastasis suppressor gene and suggest its value as a prognostic marker in gastric cancer. Development of therapies targeting signaling downstream of GPC3 are warranted. Impact Journals LLC 2016-06-01 /pmc/articles/PMC5190106/ /pubmed/27259271 http://dx.doi.org/10.18632/oncotarget.9763 Text en Copyright: © 2016 Han et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Han, Shiwei Ma, Xuemei Zhao, Yanxia Zhao, Hongying Batista, Ana Zhou, Sheng Zhou, Xiaona Yang, Yao Wang, Tingting Bi, Jingtao Xia, Zheng Bai, Zhigang Garkavtsev, Igor Zhang, Zhongtao
spellingShingle	Han, Shiwei Ma, Xuemei Zhao, Yanxia Zhao, Hongying Batista, Ana Zhou, Sheng Zhou, Xiaona Yang, Yao Wang, Tingting Bi, Jingtao Xia, Zheng Bai, Zhigang Garkavtsev, Igor Zhang, Zhongtao Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
author_facet	Han, Shiwei Ma, Xuemei Zhao, Yanxia Zhao, Hongying Batista, Ana Zhou, Sheng Zhou, Xiaona Yang, Yao Wang, Tingting Bi, Jingtao Xia, Zheng Bai, Zhigang Garkavtsev, Igor Zhang, Zhongtao
author_sort	Han, Shiwei
title	Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
title_short	Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
title_full	Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
title_fullStr	Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
title_full_unstemmed	Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
title_sort	identification of glypican-3 as a potential metastasis suppressor gene in gastric cancer
description	Gastric cancer is a prevalent tumor that is usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell carcinomas. We demonstrate that loss of GPC3 correlates with poor overall survival in patients. Moreover, we show that absence of GPC3 causes up-regulation of MAPK/FoxM1 signaling and that blockade of this pathway alters cellular invasion. An inverse correlation between GPC3 and FoxM1 is also shown in patient samples. These data identify GPC3 as a potential metastasis suppressor gene and suggest its value as a prognostic marker in gastric cancer. Development of therapies targeting signaling downstream of GPC3 are warranted.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190106/
_version_	1613830251828215808

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer

Similar Items