Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulati...

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Bibliographic Details
Main Authors: Toulany, Mahmoud, Iida, Mari, Keinath, Simone, Iyi, Firdevs F., Mueck, Katharina, Fehrenbacher, Birgit, Mansour, Wael Y., Schaller, Martin, Wheeler, Deric L., Rodemann, H. Peter
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190057/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190057/

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