Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

The androgen receptor (AR) plays a central role in prostate tumor growth. Inappropriate reactivation of the AR after androgen deprivation therapy promotes development of incurable castration-resistant prostate cancer (CRPC). In this study, we provide evidence that metabolic features of prostate canc...

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Bibliographic Details
Main Authors: Shah, Supriya, Carriveau, Whitney J., Li, Jinyang, Campbell, Sydney L., Kopinski, Piotr K., Lim, Hee-Woong, Daurio, Natalie, Trefely, Sophie, Won, Kyoung-Jae, Wallace, Douglas C., Koumenis, Constantinos, Mancuso, Anthony, Wellen, Kathryn E.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190055/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190055/

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