Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk between Pim kinases and the Notch signaling pathway, with implications for both breast and prostate cancer. We identify N...

Full description

Bibliographic Details
Main Authors: Santio, Niina M., Landor, Sebastian K.-J., Vahtera, Laura, Ylä-Pelto, Jani, Paloniemi, Elina, Imanishi, Susumu Y., Corthals, Garry, Varjosalo, Markku, Manoharan, Ganesh Babu, Uri, Asko, Lendahl, Urban, Sahlgren, Cecilia, Koskinen, Päivi J.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190019/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190019/

Similar Items