Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive assessment of immune responses that protect against SIV infection through detail...

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Bibliographic Details
Main Authors: Adnan, Sama, Reeves, R. Keith, Gillis, Jacqueline, Wong, Fay E., Yu, Yi, Camp, Jeremy V., Li, Qingsheng, Connole, Michelle, Li, Yuan, Piatak, Michael, Lifson, Jeffrey D., Li, Wenjun, Keele, Brandon F., Kozlowski, Pamela A., Desrosiers, Ronald C., Haase, Ashley T., Johnson, R. Paul
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189958/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189958/

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