miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats
In rats with type 1 diabetes mellitus (T1DM) subject to stroke, the therapeutic effects and underlying mechanisms of action of bone-marrow stromal cells (BMSCs) derived from T1DM rats (DM-BMSCs) and BMSCs derived from normal rats (Nor-BMSCs) were compared. In vitro and in vivo, DM-BMSCs exhibited de...
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| Format: | Online |
| Language: | English |
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AlphaMed Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189645/ |
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pubmed-5189645 |
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pubmed-51896452017-06-01 miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats Cui, Chengcheng Ye, Xinchun Chopp, Michael Venkat, Poornima Zacharek, Alex Yan, Tao Ning, Ruizhou Yu, Peng Cui, Guiyun Chen, Jieli Cell-Based Drug Development, Screening, and Toxicology In rats with type 1 diabetes mellitus (T1DM) subject to stroke, the therapeutic effects and underlying mechanisms of action of bone-marrow stromal cells (BMSCs) derived from T1DM rats (DM-BMSCs) and BMSCs derived from normal rats (Nor-BMSCs) were compared. In vitro and in vivo, DM-BMSCs exhibited decreased miR-145 expression. In T1DM rats, DM-BMSC treatment significantly improved functional outcome and increased vascular and white matter remodeling. However, overexpression of miR-145 in DM-BMSCs attenuates DM-BMSC-induced neurorestorative effects in T1DM stroke rats. AlphaMed Press 2016-12 2016-07-26 /pmc/articles/PMC5189645/ /pubmed/27460851 http://dx.doi.org/10.5966/sctm.2015-0349 Text en ©AlphaMed Press |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cui, Chengcheng Ye, Xinchun Chopp, Michael Venkat, Poornima Zacharek, Alex Yan, Tao Ning, Ruizhou Yu, Peng Cui, Guiyun Chen, Jieli |
| spellingShingle |
Cui, Chengcheng Ye, Xinchun Chopp, Michael Venkat, Poornima Zacharek, Alex Yan, Tao Ning, Ruizhou Yu, Peng Cui, Guiyun Chen, Jieli miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| author_facet |
Cui, Chengcheng Ye, Xinchun Chopp, Michael Venkat, Poornima Zacharek, Alex Yan, Tao Ning, Ruizhou Yu, Peng Cui, Guiyun Chen, Jieli |
| author_sort |
Cui, Chengcheng |
| title |
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| title_short |
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| title_full |
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| title_fullStr |
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| title_full_unstemmed |
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats |
| title_sort |
mir-145 regulates diabetes-bone marrow stromal cell-induced neurorestorative effects in diabetes stroke rats |
| description |
In rats with type 1 diabetes mellitus (T1DM) subject to stroke, the therapeutic effects and underlying mechanisms of action of bone-marrow stromal cells (BMSCs) derived from T1DM rats (DM-BMSCs) and BMSCs derived from normal rats (Nor-BMSCs) were compared. In vitro and in vivo, DM-BMSCs exhibited decreased miR-145 expression. In T1DM rats, DM-BMSC treatment significantly improved functional outcome and increased vascular and white matter remodeling. However, overexpression of miR-145 in DM-BMSCs attenuates DM-BMSC-induced neurorestorative effects in T1DM stroke rats. |
| publisher |
AlphaMed Press |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189645/ |
| _version_ |
1613829609200025600 |