Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous Par...

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Bibliographic Details
Main Authors: Khojah, Sohair M., Payne, Anthony P., McGuinness, Dagmara, Shiels, Paul G.
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187522/