Serum Cytokine Profiles in Children with Crohn's Disease

Crohn's disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile...

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Main Authors:	Vasilyeva, Ekaterina, Abdulkhakov, Sayar, Cherepnev, Georgi, Martynova, Ekaterina, Mayanskaya, Irina, Valeeva, Alina, Abdulkhakov, Rustam, Safina, Dilyara, Khaiboullina, Svetlana, Rizvanov, Albert
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187493/

id	pubmed-5187493
recordtype	oai_dc
spelling	pubmed-51874932017-01-09 Serum Cytokine Profiles in Children with Crohn's Disease Vasilyeva, Ekaterina Abdulkhakov, Sayar Cherepnev, Georgi Martynova, Ekaterina Mayanskaya, Irina Valeeva, Alina Abdulkhakov, Rustam Safina, Dilyara Khaiboullina, Svetlana Rizvanov, Albert Research Article Crohn's disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile CD patients. Immune mechanisms have been suggested to play an important role in CD pathogenesis, with cytokines governing the development of the immune response. Upregulation of inflammatory cytokines in serum of juvenile and adult CD patients has been documented; still little is known about age-dependent differences in serum cytokine profiles of CD patients. We applied multiplex technology to analyze serum levels of 12 cytokines in juveniles and adults. We show that during the acute stage of the disease all CD patients have high serum levels of CXCL10, which remains upregulated during remission. Increased serum levels of TNF-α and IL-6 during the acute stage was characteristic of juvenile CD patients, whereas adult CD patients had upregulated levels of GM-CSF and IFN-γ. Taken together, these results demonstrate age-dependent differences in cytokine profiles, which may affect the pathogenesis of CD in patients at different ages of disease onset. Hindawi Publishing Corporation 2016 2016-12-13 /pmc/articles/PMC5187493/ /pubmed/28070144 http://dx.doi.org/10.1155/2016/7420127 Text en Copyright © 2016 Ekaterina Vasilyeva et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Vasilyeva, Ekaterina Abdulkhakov, Sayar Cherepnev, Georgi Martynova, Ekaterina Mayanskaya, Irina Valeeva, Alina Abdulkhakov, Rustam Safina, Dilyara Khaiboullina, Svetlana Rizvanov, Albert
spellingShingle	Vasilyeva, Ekaterina Abdulkhakov, Sayar Cherepnev, Georgi Martynova, Ekaterina Mayanskaya, Irina Valeeva, Alina Abdulkhakov, Rustam Safina, Dilyara Khaiboullina, Svetlana Rizvanov, Albert Serum Cytokine Profiles in Children with Crohn's Disease
author_facet	Vasilyeva, Ekaterina Abdulkhakov, Sayar Cherepnev, Georgi Martynova, Ekaterina Mayanskaya, Irina Valeeva, Alina Abdulkhakov, Rustam Safina, Dilyara Khaiboullina, Svetlana Rizvanov, Albert
author_sort	Vasilyeva, Ekaterina
title	Serum Cytokine Profiles in Children with Crohn's Disease
title_short	Serum Cytokine Profiles in Children with Crohn's Disease
title_full	Serum Cytokine Profiles in Children with Crohn's Disease
title_fullStr	Serum Cytokine Profiles in Children with Crohn's Disease
title_full_unstemmed	Serum Cytokine Profiles in Children with Crohn's Disease
title_sort	serum cytokine profiles in children with crohn's disease
description	Crohn's disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile CD patients. Immune mechanisms have been suggested to play an important role in CD pathogenesis, with cytokines governing the development of the immune response. Upregulation of inflammatory cytokines in serum of juvenile and adult CD patients has been documented; still little is known about age-dependent differences in serum cytokine profiles of CD patients. We applied multiplex technology to analyze serum levels of 12 cytokines in juveniles and adults. We show that during the acute stage of the disease all CD patients have high serum levels of CXCL10, which remains upregulated during remission. Increased serum levels of TNF-α and IL-6 during the acute stage was characteristic of juvenile CD patients, whereas adult CD patients had upregulated levels of GM-CSF and IFN-γ. Taken together, these results demonstrate age-dependent differences in cytokine profiles, which may affect the pathogenesis of CD in patients at different ages of disease onset.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187493/
_version_	1613825968155131904

Serum Cytokine Profiles in Children with Crohn's Disease

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