MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional target and a negative regulator of TGFβ signalling, thus mediating a negative feedback loop that may potentially restrain TG...

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Bibliographic Details
Main Authors: Yu, Jingyi, Lei, Rong, Zhuang, Xueqian, Li, Xiaoxun, Li, Gang, Lev, Sima, Segura, Miguel F., Zhang, Xue, Hu, Guohong
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187443/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187443/

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