Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma

Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma

Thyrotoxicosis is most commonly caused by Graves’ disease, toxic multinodular goitre, a functioning thyroid adenoma, or thyroiditis. Extrinsic infiltrative conditions affecting the thyroid gland are typically destructive, and associated with thyroid hypofunction. We describe the case of a 61-year-ol...

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Main Authors: McCarthy, Michael T, Keyes, Michael, O'Hare, James, Shine, Neville, Gupta, Rajnish K
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184839/
id pubmed-5184839
recordtype oai_dc
spelling pubmed-51848392016-12-28 Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma McCarthy, Michael T Keyes, Michael O'Hare, James Shine, Neville Gupta, Rajnish K Case Report Thyrotoxicosis is most commonly caused by Graves’ disease, toxic multinodular goitre, a functioning thyroid adenoma, or thyroiditis. Extrinsic infiltrative conditions affecting the thyroid gland are typically destructive, and associated with thyroid hypofunction. We describe the case of a 61-year-old woman who presented to our hospital with symptoms of thyrotoxicosis, neck swelling and thyroid function tests consistent with hyperthyroidism. An ultrasound revealed a multinodular goitre with retrosternal extension, but CT imaging suggested thyroid gland infiltration, with cervical lymphadenopathy. An excisional lymph node biopsy confirmed the diagnosis of diffuse large B cell lymphoma causing infiltrative thyrotoxicosis. Treatment with six cycles of Rituximab-CHOP lead to rapid normalization of symptoms, imaging, and thyroid function. Oxford University Press 2016-11-04 /pmc/articles/PMC5184839/ /pubmed/28031847 http://dx.doi.org/10.1093/omcr/omw082 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author McCarthy, Michael T
Keyes, Michael
O'Hare, James
Shine, Neville
Gupta, Rajnish K
spellingShingle McCarthy, Michael T
Keyes, Michael
O'Hare, James
Shine, Neville
Gupta, Rajnish K
Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
author_facet McCarthy, Michael T
Keyes, Michael
O'Hare, James
Shine, Neville
Gupta, Rajnish K
author_sort McCarthy, Michael T
title Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
title_short Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
title_full Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
title_fullStr Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
title_full_unstemmed Infiltrative thyrotoxicosis: an unusual case of diffuse large B cell lymphoma
title_sort infiltrative thyrotoxicosis: an unusual case of diffuse large b cell lymphoma
description Thyrotoxicosis is most commonly caused by Graves’ disease, toxic multinodular goitre, a functioning thyroid adenoma, or thyroiditis. Extrinsic infiltrative conditions affecting the thyroid gland are typically destructive, and associated with thyroid hypofunction. We describe the case of a 61-year-old woman who presented to our hospital with symptoms of thyrotoxicosis, neck swelling and thyroid function tests consistent with hyperthyroidism. An ultrasound revealed a multinodular goitre with retrosternal extension, but CT imaging suggested thyroid gland infiltration, with cervical lymphadenopathy. An excisional lymph node biopsy confirmed the diagnosis of diffuse large B cell lymphoma causing infiltrative thyrotoxicosis. Treatment with six cycles of Rituximab-CHOP lead to rapid normalization of symptoms, imaging, and thyroid function.
publisher Oxford University Press
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184839/
_version_ 1613821516846202880

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