KLF4 functions as an activator of the androgen receptor through reciprocal feedback

In prostate cancer, Krüppel-like factor 4 (KLF4) depletion occurs frequently, suggesting a role as suppressor tumor. KLF4 is a transcription factor associated with androgen receptor (AR) expression; however, its cellular functions and signaling regulation mechanism remain largely unknown. In this st...

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Bibliographic Details
Main Authors: Siu, M-K, Suau, F, Chen, W-Y, Tsai, Y-C, Tsai, H-Y, Yeh, H-L, Liu, Y-N
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177777/