A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria
Mitochondrial dysfunction is implicated in numerous neurodegenerative disorders and in Parkinson’s disease (PD) in particular. PINK1 and Parkin gene mutations are causes of autosomal recessive PD, and these respective proteins function cooperatively to degrade depolarized mitochondria (mitophagy). I...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177631/ |