Acute Promyelocytic Leukemia with i(17)(q10)
We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochrom...
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| Format: | Online |
| Language: | English |
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The Japanese Society of Internal Medicine
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173505/ |
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pubmed-5173505 |
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pubmed-51735052016-12-27 Acute Promyelocytic Leukemia with i(17)(q10) Inamura, Junki Ikuta, Katsuya Tsukada, Nodoka Hosoki, Takaaki Shindo, Motohiro Sato, Kazuya Case Report We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARĪ± fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17). The Japanese Society of Internal Medicine 2016-11-15 /pmc/articles/PMC5173505/ /pubmed/27853080 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Inamura, Junki Ikuta, Katsuya Tsukada, Nodoka Hosoki, Takaaki Shindo, Motohiro Sato, Kazuya |
| spellingShingle |
Inamura, Junki Ikuta, Katsuya Tsukada, Nodoka Hosoki, Takaaki Shindo, Motohiro Sato, Kazuya Acute Promyelocytic Leukemia with i(17)(q10) |
| author_facet |
Inamura, Junki Ikuta, Katsuya Tsukada, Nodoka Hosoki, Takaaki Shindo, Motohiro Sato, Kazuya |
| author_sort |
Inamura, Junki |
| title |
Acute Promyelocytic Leukemia with i(17)(q10) |
| title_short |
Acute Promyelocytic Leukemia with i(17)(q10) |
| title_full |
Acute Promyelocytic Leukemia with i(17)(q10) |
| title_fullStr |
Acute Promyelocytic Leukemia with i(17)(q10) |
| title_full_unstemmed |
Acute Promyelocytic Leukemia with i(17)(q10) |
| title_sort |
acute promyelocytic leukemia with i(17)(q10) |
| description |
We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARĪ± fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17). |
| publisher |
The Japanese Society of Internal Medicine |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173505/ |
| _version_ |
1613804859626094592 |