IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain. Here we show that Bcl2l10 and IRBIT interact and exert an additive inhibition of IP3R...

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Bibliographic Details
Main Authors: Bonneau, Benjamin, Ando, Hideaki, Kawaai, Katsuhiro, Hirose, Matsumi, Takahashi-Iwanaga, Hiromi, Mikoshiba, Katsuhiko
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173324/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173324/

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