MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires identification of novel targets for its treatment. This multifactorial disease accounts for about 15% of the all diagnosed leukemia cases. Mitogen-activated protein kinase (MAPK) signaling pathway is crucial for the...

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Main Authors:	Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Patra, Bidhan Chandra, Bhattacharya, Manojit, Sharma, Garima, Lee, Sang-Soo
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173166/

id	pubmed-5173166
recordtype	oai_dc
spelling	pubmed-51731662016-12-23 MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia Chakraborty, Chiranjib Sharma, Ashish Ranjan Patra, Bidhan Chandra Bhattacharya, Manojit Sharma, Garima Lee, Sang-Soo Review Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires identification of novel targets for its treatment. This multifactorial disease accounts for about 15% of the all diagnosed leukemia cases. Mitogen-activated protein kinase (MAPK) signaling pathway is crucial for the cell survival and its dysregulation is being implicated in various types of cancers. In here, we have discussed the potential role of various miRNAs that are found involved in regulating the proteins cascades of MAPK signaling pathway associated with CML. An emphasis has been paid to summarize the influence of various miRNAs in elevating or suppressing the expression level of significant proteins such as miR-203, miR-196a, miR-196b, miR-30a, miR-29b, miR-138 in BCR-ABL tyrosine kinase; miR-126, miR-221, miR-128, miR-15a, miR-188-5p, miR-17 in CRK family proteins; miR-155, miR-181a with SOS proteins; miR-155, miR-19a, with KRAS proteins; miR-19a with RAF1 protein; and miR-17, miR-19a, miR-17-92 cluster with MAPK/ERK proteins. In light of ever-increasing importance and ever-widening regulatory roles of miRNAs in cells, we have reviewed the recent progress in the field of miRNAs and have tried to suggest them as controlling targets for various protein cascades of MAPK signaling pathway. An understanding of the supervisory mechanism of MAPK by miRNAs might provide novel targets for treating CML. Impact Journals LLC 2016-03-08 /pmc/articles/PMC5173166/ /pubmed/26967056 http://dx.doi.org/10.18632/oncotarget.7977 Text en Copyright: © 2016 Chakraborty et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chakraborty, Chiranjib Sharma, Ashish Ranjan Patra, Bidhan Chandra Bhattacharya, Manojit Sharma, Garima Lee, Sang-Soo
spellingShingle	Chakraborty, Chiranjib Sharma, Ashish Ranjan Patra, Bidhan Chandra Bhattacharya, Manojit Sharma, Garima Lee, Sang-Soo MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
author_facet	Chakraborty, Chiranjib Sharma, Ashish Ranjan Patra, Bidhan Chandra Bhattacharya, Manojit Sharma, Garima Lee, Sang-Soo
author_sort	Chakraborty, Chiranjib
title	MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
title_short	MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
title_full	MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
title_fullStr	MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
title_full_unstemmed	MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
title_sort	micrornas mediated regulation of mapk signaling pathways in chronic myeloid leukemia
description	Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires identification of novel targets for its treatment. This multifactorial disease accounts for about 15% of the all diagnosed leukemia cases. Mitogen-activated protein kinase (MAPK) signaling pathway is crucial for the cell survival and its dysregulation is being implicated in various types of cancers. In here, we have discussed the potential role of various miRNAs that are found involved in regulating the proteins cascades of MAPK signaling pathway associated with CML. An emphasis has been paid to summarize the influence of various miRNAs in elevating or suppressing the expression level of significant proteins such as miR-203, miR-196a, miR-196b, miR-30a, miR-29b, miR-138 in BCR-ABL tyrosine kinase; miR-126, miR-221, miR-128, miR-15a, miR-188-5p, miR-17 in CRK family proteins; miR-155, miR-181a with SOS proteins; miR-155, miR-19a, with KRAS proteins; miR-19a with RAF1 protein; and miR-17, miR-19a, miR-17-92 cluster with MAPK/ERK proteins. In light of ever-increasing importance and ever-widening regulatory roles of miRNAs in cells, we have reviewed the recent progress in the field of miRNAs and have tried to suggest them as controlling targets for various protein cascades of MAPK signaling pathway. An understanding of the supervisory mechanism of MAPK by miRNAs might provide novel targets for treating CML.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173166/
_version_	1613804514136031232

MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia

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