Evolution of multiple cell clones over a 29-year period of a CLL patient

Chronic lymphocytic leukaemia (CLL) is a frequent B-cell malignancy, characterized by recurrent somatic chromosome alterations and a low level of point mutations. Here we present single-nucleotide polymorphism microarray analyses of a single CLL patient over 29 years of observation and treatment, an...

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Bibliographic Details
Main Authors: Zhao, Zhikun, Goldin, Lynn, Liu, Shiping, Wu, Liang, Zhou, Weiyin, Lou, Hong, Yu, Qichao, Tsang, Shirley X., Jiang, Miaomiao, Li, Fuqiang, McMaster, MaryLou, Li, Yang, Lin, Xinxin, Wang, Zhifeng, Xu, Liqin, Marti, Gerald, Li, Guibo, Wu, Kui, Yeager, Meredith, Yang, Huanming, Xu, Xun, Chanock, Stephen J., Li, Bo, Hou, Yong, Caporaso, Neil, Dean, Michael
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171825/